Alpl Gene Summary [Rat]
Enables alkaline phosphatase activity. Involved in several processes, including cementum mineralization; response to insulin; and response to macrophage colony-stimulating factor. Located in extracellular space. Is active in extracellular membrane-bounded organelle. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alpl |
| Official Name | alkaline phosphatase, biomineralization associated [Source:RGD Symbol;Acc:2100] |
| Ensembl ID | ENSRNOG00000013954 |
| Bio databases IDs | |
| Aliases | alkaline phosphatase, biomineralization associated |
| Synonyms | AKP2, alkaline phosphatase, biomineralization associated, ALKALINE PHOSPHATASE BONE isoform, alkaline phosphatase, liver/bone/kidney, ALP, Alp2, AP-TNAP, BALP, BAP, Biliary ALP Isoenzyme (ALP1), BSAP, HOPS, HPPA, HPPC, HPPI, HPPO, NAP, PHOA, Placental alkaline phospatase, plap, TNALP, TNAP, TNS-ALP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- alkaline phosphatase
- Alkaline phosphatase homologues
- phosphoamidase
- pyrophosphatase
- phosphatase
- calcium ion binding
- protein binding
Pathways
Biological processes and signaling networks where the Alpl gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- neoplasia
- seizures
- COVID-19
- hypophosphatasia
- skeletal dysplasia
- adult hypophosphatasia
- infantile hypophosphatasia
- hypertension
role in cell
- number
- abnormal morphology
- endochondral ossification by
- activation in
- hydrolysis in
- homeostasis
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- organelle
- Extracellular Space
- cellular membrane
- Nucleus
- mitochondrial membrane
- mitochondrial intermembrane space
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyridoxal phosphate metabolic process
- cellular homeostasis
- cementum mineralization
- phosphate ion homeostasis
- response to vitamin D
- calcium ion homeostasis
- bone mineralization
- response to antibiotic
- developmental process involved in reproduction
- skeletal system development
- response to insulin stimulus
- response to glucocorticoid stimulus
- osteoblast differentiation
- endochondral ossification
- response to lipopolysaccharide
- response to vitamin B6
- response to macrophage colony-stimulating factor stimulus
- dephosphorylation
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial membrane
- extracellular vesicular exosome
- membrane
- extracellular matrix
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- phosphoethanolamine phosphatase activity
- inorganic diphosphatase activity
- adenosine-diphosphatase activity
- calcium ion binding
- phosphoamidase activity
- pyrophosphatase activity
- pyridoxal phosphatase activity
- alkaline phosphatase activity