Gdf5 Gene Summary [Rat]
Enables signaling receptor binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; ossification involved in bone remodeling; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and bone disease (multiple). Orthologous to human GDF5 (growth differentiation factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdf5 |
| Official Name | growth differentiation factor 5 [Source:RGD Symbol;Acc:620102] |
| Ensembl ID | ENSRNOG00000050123 |
| Bio databases IDs | |
| Aliases | growth differentiation factor 5 |
| Synonyms | BDA1C, BDC, BMP-14, bp, brp, cartilage-derived morphogenetic protein-1, CDMP1, DUPANS, growth differentiation factor 5, LAP-4, OS5, SYM1B, SYNS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gdf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- identical protein binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Gdf5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- knee pain
- osteoarthritis
- hip or knee osteoarthritis
- brachydactyly type A2
- prostate cancer
- proximal symphalangism type 1B
- brachydactyly type C
- grebe syndrome
- knee osteoarthritis
- brachydactyly type A1C
role in cell
- apoptosis
- proliferation
- migration
- adhesion
- quantity
- differentiation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gdf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of multicellular organism growth
- negative regulation of mesenchymal cell apoptotic process
- chondroblast differentiation
- transforming growth factor beta receptor signaling pathway
- chondrocyte differentiation
- cell-cell signaling
- positive regulation of neuron differentiation
- ossification involved in bone remodeling
- mesenchymal cell apoptotic process
- response to mechanical stimulus
- negative regulation of neuron apoptotic process
- positive regulation of BMP signaling pathway
- embryonic limb morphogenesis
- BMP signaling pathway
- negative regulation of epithelial cell proliferation
- negative regulation of chondrocyte differentiation
- positive regulation of SMAD protein import into nucleus
- positive regulation of chondrocyte differentiation
- forelimb morphogenesis
- hindlimb morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- BMP binding
- growth factor activity
- identical protein binding
- protein binding
- cytokine activity