PTGDR2 Gene Summary [Human]
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | PTGDR2 |
| Official Name | prostaglandin D2 receptor 2 [Source:HGNC Symbol;Acc:HGNC:4502] |
| Ensembl ID | ENSG00000183134 |
| Bio databases IDs | |
| Aliases | prostaglandin D2 receptor 2, chemoattractant receptor homologous molecule expressed on T helper type 2 cells |
| Synonyms | CD294, CRTH2, DL1R, DP2, DP2 receptor, GPR44, Grp45, prostaglandin D2 receptor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGDR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin receptor
- prostaglandin F receptor
- Cholecystokinin A receptor, N-terminal
- prostaglandin D receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGDR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- eosinophilia
- hepatic fibrosis
- COVID-19
- chronic periodontal disease
- asthma
- atopic dermatitis
- primary pulmonary hypertension
- myocardial fibrosis
- pulmonary fibrosis
role in cell
- migration
- quantity
- expression in
- activation
- number
- survival
- chemotaxis
- cellular infiltration by
- recruitment
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGDR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- chemotaxis
- neuropeptide signaling pathway
- immune response
- G-protein coupled receptor signaling pathway
- negative regulation of male germ cell proliferation
- calcium-mediated signaling
- positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- prostaglandin J receptor activity
- neuropeptide binding
- prostaglandin D receptor activity
- prostaglandin F receptor activity