RHOT2 Gene Summary [Human]
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | RHOT2 |
| Official Name | ras homolog family member T2 [Source:HGNC Symbol;Acc:HGNC:21169] |
| Ensembl ID | ENSG00000140983 |
| Bio databases IDs | |
| Aliases | ras homolog family member T2, mitochondrial Rho (MIRO) GTPase 2 |
| Synonyms | ARHT2, C16orf39, MIRO-2, ras homolog family member T2, RASL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHOT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- EF hand associated
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the RHOT2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
role in cell
- binding
- axonal transport
- axonal transport in
- budding
- molecular cleavage in
- permeabilization
- pausing in
- homeostasis
- pausing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHOT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
- small GTPase mediated signal transduction
- mitochondrion transport along microtubule
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- calcium ion binding
- GTPase activity