Dok2 Gene Summary [Mouse]
Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within Ras protein signal transduction and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and lung. Orthologous to human DOK2 (docking protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dok2 |
| Official Name | docking protein 2 [Source:MGI Symbol;Acc:MGI:1332623] |
| Ensembl ID | ENSMUSG00000022102 |
| Bio databases IDs | |
| Aliases | docking protein 2 |
| Synonyms | Doc2, docking protein 2, DokR, Frip, p56DOK, p56dok-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dok2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline-methionine-methionine-proline motif
- PTB domain (IRS-1 type)
- proline and tyrosine-rich region
- Rasgap binding domain
- PH domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- proline-glutamic acid-serine-proline motif
- proline-glycine-alanine-proline motif
- Nck-binding domain
Pathways
Biological processes and signaling networks where the Dok2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- atopic dermatitis
- splenomegaly
- pancreatic epithelial cancer
- tumorigenesis
- leukemia
- androgenic alopecia
- lung cancer
- myeloproliferative disorder
- diabetes mellitus
role in cell
- migration
- proliferation
- development
- phosphorylation in
- cell viability
- invasion by
- quantity
- function
- number
- transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dok2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell surface receptor signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity