Rasgrf1 Gene Summary [Rat]
Enables receptor tyrosine kinase binding activity and small GTPase binding activity. Involved in several processes, including activation of GTPase activity; modulation of chemical synaptic transmission; and positive regulation of Ras protein signal transduction. Located in several cellular components, including apical dendrite; apicolateral plasma membrane; and basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Biomarker of fetal alcohol spectrum disorder. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasgrf1 |
| Official Name | RAS protein-specific guanine nucleotide-releasing factor 1 [Source:RGD Symbol;Acc:620395] |
| Ensembl ID | ENSRNOG00000014025 |
| Bio databases IDs | |
| Aliases | RAS protein-specific guanine nucleotide-releasing factor 1 |
| Synonyms | AI844718, CDC25, CDC25L, CDC25Mm, GNRP, GRF1, GRF55, Grfbeta, Guanine nucleotide release/exchange factor, H-GRF55, LOC145899, P140 RAS-GRF, p190, P190A, p190RhoGEF, PP13187, RAS-GEF, Ras-grf p140, RAS protein-specific guanine nucleotide-releasing factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rasgrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- enzyme binding
- coiled-coil domain
- GTPase activator
- Cdc25 domain
- protein binding
- RasGEF
- receptor binding
- Pleckstrin homology-like domain
- RhoGEF domain
- RhoGEF
- receptor tyrosine kinase binding
- guanyl-nucleotide exchange factor
- Ras-binding domain
- IQ domain
- PH domain
- Dbl homology domain
Pathways
Biological processes and signaling networks where the Rasgrf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplastic cell transformation
- rheumatoid arthritis
- metastasis
- ischemic injury
- hyperactive behavior
- endometriosis
- early onset hypertension
- growth failure
- myopia
- liver cancer
role in cell
- expression in
- proliferation
- outgrowth
- size
- damage
- production in
- activation in
- growth
- expansion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apicolateral membrane
- glutaminergic synapse
- cell periphery
- postsynaptic region
- filamentous network
- Plasma Membrane
- microtubules
- cytosol
- basolateral membrane
- growth cone
- perikaryon
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rasgrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- neuron projection development
- regulation of Rac protein signal transduction
- regulation of Ras protein signal transduction
- positive regulation of Ras protein signal transduction
- Ras protein signal transduction
- positive regulation of GTPase activity
- long-term memory
- regulation of neuronal synaptic plasticity
- type B pancreatic cell proliferation
- regulation of synaptic plasticity
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytosol
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding
- guanyl-nucleotide exchange factor activity