Map3k5 Gene Summary [Rat]
Enables MAP kinase kinase kinase activity. Involved in several processes, including endothelial cell apoptotic process; positive regulation of MAPK cascade; and positive regulation of cardiac muscle cell apoptotic process. Located in external side of plasma membrane. Used to study cerebral infarction and myocardial infarction. Biomarker of membranous glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k5 |
| Official Name | mitogen-activated protein kinase kinase kinase 5 [Source:RGD Symbol;Acc:1306565] |
| Ensembl ID | ENSRNOG00000031700 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 5 |
| Synonyms | 7420452D20Rik, APOPTOSIS SIGNAL REGULATED KINASE 1, ASK, ASK1, M3K5, MAPKKK5, MEKK5, mitogen-activated protein kinase kinase kinase 5, RGD1306565 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map3k5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- C-terminal regulatory domain
- ATP-binding domain
- HisK-N-like globin domain of the ASK signalosome
- ATP binding
- ASK1 kinase domain
- coiled-coil domain
- inhibitory domain
- LXCXE binding site
- Protein kinase domain
- identical protein binding
- MAP3K TRAFs-binding domain
- Tetratricopeptide Repeats-Sensor
- Deoxyribohydrolase (DRHyd) domain of the ASK signalosome
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Akt phosphorylation site
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- JUN kinase kinase kinase
- protein domain specific binding
- protein binding
- magnesium ion binding
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- ASK kinase PH domain
- Protein Kinases, catalytic domain
- protein homodimerization
Pathways
Biological processes and signaling networks where the Map3k5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Acute Phase Response Signaling
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Death Receptor Signaling
- Endoplasmic Reticulum Stress Pathway
- FGF Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Molecular Mechanisms of Cancer
- Natural Killer Cell Signaling
- Neurotrophin/TRK Signaling
- NRF2-mediated Oxidative Stress Response
- p38 MAPK Signaling
- RANK Signaling in Osteoclasts
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Sertoli Cell-Sertoli Cell Junction Signaling
- Type II Diabetes Mellitus Signaling
- Unfolded protein response
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- experimental Huntington disease
- early-onset preeclampsia
- endotoxin shock response
- systemic lupus erythematosus
- nonalcoholic steatohepatitis
- cardiomyopathy
- cardiac injury
- necrotizing enterocolitis
- cardiac fibrosis
role in cell
- phosphorylation in
- accumulation in
- generation in
- cell death
- activation in
- apoptosis
- expression in
- formation
- degradation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- sarcomere
- cytosol
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map3k5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- cellular response to amino acid starvation
- cellular senescence
- apoptotic signaling pathway
- JNK cascade
- positive regulation of myoblast differentiation
- protein phosphorylation
- MAPK cascade
- programmed necrotic cell death
- response to ischemia
- positive regulation of transcription, DNA-dependent
- cellular response to stress
- cellular response to tumor necrosis factor
- cellular response to hydrogen peroxide
- neuron apoptotic process
- stress-activated MAPK cascade
- p38MAPK cascade
- induction of apoptosis by oxidative stress
- positive regulation of p38MAPK cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of protein kinase activity
- positive regulation of JNK cascade
- innate immune response
- positive regulation of apoptotic process
- positive regulation of cardiac muscle cell apoptotic process
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- endothelial cell apoptotic process
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- identical protein binding
- protein homodimerization activity
- protein phosphatase binding
- protein kinase activity
- protein serine/threonine kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- JUN kinase kinase kinase activity
- MAP kinase kinase kinase activity