p53 Signaling
The p53 (TP53) tumor suppressor protein is a key transcriptional regulator that responds to a variety of cellular stresses such as DNA damage, UV irradiation and hypoxia. Loss of p53 function is thought to play a role in many cancers, as p53-dependent pathways act to shut down damaged cells.
Pathway Summary
The p53 (TP53) tumor suppressor protein is a key transcriptional regulator that responds to a variety of cellular stresses such as DNA damage, UV irradiation, and hypoxia. p53 regulates key cellular processes such as DNA repair, cell-cycle progression, angiogenesis, and apoptosis. These p53-dependent pathways shut down damaged cells, either through apoptosis or cell-cycle arrest. Loss of p53 function is thought to be a contributing factor in the majority of cancer cases.
p53 Signaling Genes list
Explore Genes related to p53 Signaling
ADGRB1
Human
adhesion G protein-coupled receptor B1
APAF1
Human
apoptotic peptidase activating factor 1
BAX
Human
BCL2 associated X, apoptosis regulator
BIRC5
Human
baculoviral IAP repeat containing 5
CDKN1A
Human
cyclin dependent kinase inhibitor 1A
DRAM1
Human
DNA damage regulated autophagy modulator 1
GADD45A
Human
growth arrest and DNA damage inducible alpha
GADD45B
Human
growth arrest and DNA damage inducible beta
GADD45G
Human
growth arrest and DNA damage inducible gamma
GML
Human
glycosylphosphatidylinositol anchored molecule like
GSK3B
Human
glycogen synthase kinase 3 beta
HIF1A
Human
hypoxia inducible factor 1 subunit alpha
HIPK2
Human
homeodomain interacting protein kinase 2
JMY
Human
junction mediating and regulatory protein, p53 cofactor
JUN
Human
Jun proto-oncogene, AP-1 transcription factor subunit
MAPK14
Human
mitogen-activated protein kinase 14
MAPK8
Human
mitogen-activated protein kinase 8
PCNA
Human
proliferating cell nuclear antigen
PERP
Human
p53 apoptosis effector related to PMP22
PIAS1
Human
protein inhibitor of activated STAT 1
PIDD1
Human
p53-induced death domain protein 1
PIK3C2A
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
PIK3C2B
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
PIK3C2G
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
PIK3C3
Human
phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3CA
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PIK3CG
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
PIK3R1
Human
phosphoinositide-3-kinase regulatory subunit 1
PIK3R2
Human
phosphoinositide-3-kinase regulatory subunit 2
PIK3R3
Human
phosphoinositide-3-kinase regulatory subunit 3
PIK3R4
Human
phosphoinositide-3-kinase regulatory subunit 4
PIK3R5
Human
phosphoinositide-3-kinase regulatory subunit 5
PIK3R6
Human
phosphoinositide-3-kinase regulatory subunit 6
PMAIP1
Human
phorbol-12-myristate-13-acetate-induced protein 1
PPP1R13B
Human
protein phosphatase 1 regulatory subunit 13B
PRKDC
Human
protein kinase, DNA-activated, catalytic subunit
RPRM
Human
reprimo, TP53 dependent G2 arrest mediator homolog
RRM2B
Human
ribonucleotide reductase regulatory TP53 inducible subunit M2B
SCO2
Human
synthesis of cytochrome C oxidase 2
SNAI2
Human
snail family transcriptional repressor 2
TIGAR
Human
TP53 induced glycolysis regulatory phosphatase
TNFRSF10A
Human
TNF receptor superfamily member 10a
TNFRSF10B
Human
TNF receptor superfamily member 10b
TOPBP1
Human
DNA topoisomerase II binding protein 1
TP53AIP1
Human
tumor protein p53 regulated apoptosis inducing protein 1
TP53BP2
Human
tumor protein p53 binding protein 2
TP53I3
Human
tumor protein p53 inducible protein 3
TP53INP1
Human
tumor protein p53 inducible nuclear protein 1
TRIM29
Human
tripartite motif containing 29