Irgm1 Gene Summary [Mouse]
Enables GTPase activity and anion binding activity. Involved in several processes, including positive regulation of leukocyte activation; positive regulation of macroautophagy; and regulation of defense response. Acts upstream of or within cellular response to type II interferon and response to bacterium. Located in cytoplasmic vesicle and vacuole. Is active in Golgi membrane; lysosomal membrane; and mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Irgm1 |
| Official Name | immunity-related GTPase family M member 1 [Source:MGI Symbol;Acc:MGI:107567] |
| Ensembl ID | ENSMUSG00000046879 |
| Bio databases IDs | |
| Aliases | immunity-related GTPase family M member 1 |
| Synonyms | Ifggd3, Ifi1, Iigp3, Iipg3, immunity-related GTPase family M member 1, immunity-related GTPase M, Irgm, LT629149.9, LT629152.10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irgm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- phospholipid binding
- protein kinase binding
- small monomeric GTPase
- protein binding activity, bridging
- 50S ribosome-binding GTPase
- GTPase
- protein domain specific binding
- enzyme
- protein kinase activator
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- Interferon-inducible GTPase (IIGP)
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- colitis
- insulin-dependent diabetes mellitus
- lymphomyeloid failure
- dextran sodium sulfate-induced colitis
- early onset hypertension
- hyperplasia
- infection by Trypanosoma cruzi
- infection by Mycobacterium avium
phenotypes
- abnormal eye morphology
- decreased circulating amylase level
- decreased circulating fructosamine level
- decreased circulating glucose level
- decreased circulating serum albumin level
- decreased circulating triglyceride level
- decreased erythrocyte cell number
- decreased fasting circulating glucose level
- decreased hematocrit
- decreased hemoglobin content
- decreased leukocyte cell number
- improved glucose tolerance
- increased circulating LDL cholesterol level
- increased circulating alkaline phosphatase level
- increased circulating cholesterol level
- increased lean body mass
- increased mean platelet volume
- increased red blood cell distribution width
- thrombocytopenia
- abnormal circulating LDL cholesterol level
- abnormal circulating cholesterol level
- abnormal hematocrit
- abnormal platelet cell number
- abnormal platelet volume
- abnormal red blood cell distribution width
- increased circulating interferon-gamma level
- increased circulating interleukin-12 level
- increased susceptibility to bacterial infection
- increased susceptibility to parasitic infection
role in cell
- adhesion
- cell death
- apoptosis
- expression in
- quantity
- binding in
- production in
- degradation in
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- phagolysosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- Golgi membrane
- mitochondrial membrane
- lysosome membrane
- autophagic vacuoles
- late endosomes
- autolysosomes
- phagosomes
- phagocytic cups