Ticam1 Gene Summary [Mouse]
Enables signaling adaptor activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of lymphocyte activation; and positive regulation of metabolic process. Located in cytosol and mitochondrion. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ticam1 |
| Official Name | toll-like receptor adaptor molecule 1 [Source:MGI Symbol;Acc:MGI:2147032] |
| Ensembl ID | ENSMUSG00000047123 |
| Bio databases IDs | |
| Aliases | toll-like receptor adaptor molecule 1 |
| Synonyms | AW046014, IIAE6, MyD88-3, PRVTIRB, TIR domain containing adaptor molecule 1, TOLL-LIKE receptor ADAPTOR MOLECULE 1, TRIF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ticam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- protein kinase binding
- protein binding activity, bridging
- TBK1-binding domain
- SEFIR domain
- protein binding
- TIR domain
- TRAF6 binding domain
- TRIF N-terminal domain
- receptor interacting protein homotypic interaction motif
- BB loop
- RIP homotypic interaction motif
- Toll IL-1 receptor domain helix B
Pathways
Biological processes and signaling networks where the Ticam1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- weight loss
- infection
- infection by bacteria
- infection by virus
- susceptibility to herpes simplex encephalitis type 4
- hypersensitivity reaction type I
- airway hyperresponsiveness
- acute lung injury
- bronchoconstriction
phenotypes
- abnormal B cell activation
- abnormal B cell physiology
- abnormal NK T cell physiology
- abnormal NK cell physiology
- abnormal chemokine level
- abnormal circulating tumor necrosis factor level
- abnormal cytokine level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal enterocyte physiology
- abnormal forced expiratory flow rates
- abnormal interleukin level
- abnormal macrophage physiology
- abnormal microglial cell physiology
- abnormal postnatal growth/weight/body size
- abnormal respiratory function
- abnormal response to infection
- abnormal retinal progenitor cell morphology
- altered susceptibility to Poxviridae infection
- decreased CD8-positive alpha-beta T cell number
- decreased IgG level
- decreased IgG2a level
- decreased Ly6C low monocyte number
- decreased circulating interferon-gamma level
- decreased circulating interleukin-12b level
- decreased circulating interleukin-6 level
- decreased circulating tumor necrosis factor level
- decreased interferon-beta secretion
- decreased interleukin-12b secretion
- decreased interleukin-6 secretion
- decreased macrophage apoptosis
- decreased macrophage cytokine production
- decreased macrophage nitric oxide production
- decreased splenocyte proliferation
- decreased susceptibility to Orthomyxoviridae infection
- decreased susceptibility to bacterial infection
- decreased susceptibility to endotoxin shock
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to induced colitis
- decreased susceptibility to injury
- decreased susceptibility to type I hypersensitivity reaction
- decreased susceptibility to weight loss
- decreased tumor necrosis factor secretion
- impaired macrophage phagocytosis
- impaired natural killer cell mediated cytotoxicity
- impaired neutrophil recruitment
- increased Ly6C high monocyte number
- increased airway responsiveness
- increased interferon-beta secretion
- increased macrophage cell number
- increased neutrophil cell number
- increased plasmacytoid dendritic cell number
- increased susceptibility to Coronaviridae infection
- increased susceptibility to Coronaviridae infection induced morbidity/mortality
- increased susceptibility to Herpesvirales infection
- increased susceptibility to Picornaviridae infection
- increased susceptibility to Picornaviridae infection induced morbidity/mortality
- increased susceptibility to bacterial infection
- increased tumor growth/size
- lung hemorrhage
- myocarditis
role in cell
- proliferation
- cell death
- apoptosis
- production in
- expression in
- killing
- phosphorylation in
- activation in
- cellular infiltration by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- endosomes
- Mitochondria
- lipid droplets
- cytosol
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ticam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- macrophage activation involved in immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- apoptotic signaling pathway
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of macrophage cytokine production
- inflammatory response
- positive regulation of myeloid dendritic cell cytokine production
- positive regulation of interferon-beta production
- response to exogenous dsRNA
- positive regulation of protein ubiquitination
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- B cell proliferation
- regulation of protein complex assembly
- toll-like receptor signaling pathway
- positive regulation of autophagy
- cellular response to lipopolysaccharide
- innate immune response
- positive regulation of gene expression
- positive regulation of natural killer cell activation
- toll-like receptor 3 signaling pathway
- positive regulation of B cell proliferation
- lipopolysaccharide-mediated signaling pathway
- nitric oxide biosynthetic process
- positive regulation of interleukin-6 production
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- mitochondrion
- cytosol
- endosome membrane
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- signaling adaptor activity
- binding, bridging