Il22 Gene Summary [Mouse]
Enables cytokine activity. Involved in negative regulation of inflammatory response. Acts upstream of or within reactive oxygen species metabolic process and regulation of macromolecule metabolic process. Is active in extracellular space. Is expressed in ileum; retina; and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il22 |
| Official Name | interleukin 22 [Source:MGI Symbol;Acc:MGI:1355307] |
| Ensembl ID | ENSMUSG00000074695 |
| Bio databases IDs | |
| Aliases | interleukin 22 |
| Synonyms | If2b1, If2b2, Il22, IL-22a, Il22b, Iltif, ILTIFa, IL-TIFb, interleukin 22, interleukin 22B |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the Il22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- cytokine receptor type II
disease
- cancer
- metastasis
- preterm birth
- colitis
- airway hyperresponsiveness
- depressive disorder
- experimental autoimmune uveitis
- experimental colitis
- atopic dermatitis
- dermatitis
phenotypes
- abnormal circulating cytokine level
- abnormal colon morphology
- abnormal cytokine secretion
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal skin morphology
- abnormal wound healing
- acanthosis
- colitis
- decreased body weight
- decreased circulating interleukin-1 alpha level
- decreased circulating interleukin-12 level
- decreased circulating interleukin-12b level
- decreased circulating tumor necrosis factor level
- decreased neutrophil cell number
- decreased physiological sensitivity to xenobiotic
- delayed wound healing
- ear inflammation
- increased circulating alanine transaminase level
- increased circulating aspartate transaminase level
- increased circulating interleukin-17 level
- increased incidence of tumors by chemical induction
- increased interleukin-17 secretion
- increased physiological sensitivity to xenobiotic
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to endotoxin shock
- increased susceptibility to fungal infection
- increased susceptibility to induced colitis
- liver inflammation
- lung inflammation
- mixed cellular infiltration to dermis
- multifocal hepatic necrosis
- thick dermal layer
role in cell
- expression in
- quantity
- proliferation
- production in
- differentiation
- apoptosis
- growth
- cell death
- upregulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space