PIK3R3 Gene Summary [Human]
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | PIK3R3 |
| Official Name | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] |
| Ensembl ID | ENSG00000117461 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase regulatory subunit 3, phosphoinositide-3-kinase regulatory subunit gamma |
| Synonyms | LOC102724021, LOC105378695, p55, p55-GAMMA, p55PIK, p55-γ, p85 Gamma, p85 γ, phosphoinositide-3-kinase regulatory subunit 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIK3R3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- phosphatidylinositol 3-kinase regulator
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- iSH2_PI3K_IA_R
- inter-SH2 domain
Pathways
Biological processes and signaling networks where the PIK3R3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- ErbB Signaling
- ErbB4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- epithelial cancer
- pancreatic cancer
- hearing loss
- uterine leiomyoma
- leiomyomatosis
- Turner syndrome
- HER2 negative hormone receptor negative breast cancer
- moderately differentiated adenocarcinoma of sigmoid colon
- sigmoid colon cancer
role in cell
- expression in
- differentiation
- growth
- migration
- invasion by
- proliferation
- metastatic potential
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIK3R3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- insulin receptor signaling pathway
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol phosphorylation
- cell migration involved in sprouting angiogenesis
- T cell differentiation
- protein kinase B signaling cascade
- immune response
- negative regulation of anoikis
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- phosphatidylinositol 3-kinase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity
- 1-phosphatidylinositol-3-kinase activity