IL-10 Signaling
Interleukin 10 (IL-10) is a cytokine with diverse, but mostly anti-inflammatory, effects on hematopoietic cells. It also regulates the growth and differentiation of B-cells, T-cells, NK-cells and dendritic cells.IL-10 binds IL-10Rα, the ligand binding chain of the tetrameric receptor. IL-10Rbeta serves to assemble the active receptor complexes and is shared with other IL-10 related cytokines. The binding of ligand to IL-10Rα induces a conformational change that enables IL-10Rβ to interact with the newly formed ligand-receptor complex...
Pathway Summary
Interleukin 10 (IL-10) is a cytokine with diverse, but mostly anti-inflammatory, effects on hematopoietic cells. It also regulates the growth and differentiation of B-cells, T-cells, NK-cells and dendritic cells.IL-10 binds IL-10Rα, the ligand binding chain of the tetrameric receptor. IL-10Rbeta serves to assemble the active receptor complexes and is shared with other IL-10 related cytokines. The binding of ligand to IL-10Rα induces a conformational change that enables IL-10Rβ to interact with the newly formed ligand-receptor complex. This in turn initiates a signal transduction cascade that activates TYK2 and JAK1 followed by STAT3. STAT3 homodimerizes and translocates into the nucleus. SOCS-3 (suppressor of cytokine signaling-3) inhibits JAK/STAT-dependent signaling, thus inhibiting pro-inflammatory genes like IL-1 and TNF-α.IL-1 binds to its cell surface receptor and initiates a signaling cascade via the adapter proteins TRAF6 and TAK1. TAK1 activates several downstream signaling pathways including the NIK/IKK/NF-κB, MKK4/JNK1 and MKK3/p38MAPK pathways. Activated NF-κB, JNK1 and p38MAPK translocate to the nucleus where, either directly or via transcriptional regulators like ELK-1, c-Jun and c-Fos, they induce genes that promote inflammation. (Upgraded 04/2022)
IL-10 Signaling Genes list
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AHRaryl hydrocarbon receptor AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 ARG2arginase 2 ATF2activating transcription factor 2 ATF4activating transcription factor 4 BCL2BCL2 apoptosis regulator BCL2L1BCL2 like 1 BCL3BCL3 transcription coactivator BHLHE40basic helix-loop-helix family member e40 BLVRAbiliverdin reductase A BLVRBbiliverdin reductase B BMP2bone morphogenetic protein 2 CCN4cellular communication network factor 4 CCND1cyclin D1 CCR1C-C motif chemokine receptor 1 CCR5C-C motif chemokine receptor 5 CD80CD80 molecule CD86CD86 molecule CDKN1Acyclin dependent kinase inhibitor 1A CDKN2Dcyclin dependent kinase inhibitor 2D CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex CREB1cAMP responsive element binding protein 1 CREB3cAMP responsive element binding protein 3 CREB3L1cAMP responsive element binding protein 3 like 1 CREB3L2cAMP responsive element binding protein 3 like 2 CREB3L3cAMP responsive element binding protein 3 like 3 CREB3L4cAMP responsive element binding protein 3 like 4 CREB5cAMP responsive element binding protein 5 CREBBPCREB binding protein DDIT4DNA damage inducible transcript 4 DUSP1dual specificity phosphatase 1 ELK1ETS transcription factor ELK1 ELP1elongator acetyltransferase complex subunit 1 FCGR2AFc fragment of IgG receptor IIa FCGR2BFc fragment of IgG receptor IIb FCGR2CFc fragment of IgG receptor IIc (gene/pseudogene) FFAR2free fatty acid receptor 2 FOSFos proto-oncogene, AP-1 transcription factor subunit GSK3Bglycogen synthase kinase 3 beta HIF1Ahypoxia inducible factor 1 subunit alpha HLA-Amajor histocompatibility complex, class I, A HLA-Bmajor histocompatibility complex, class I, B HLA-Cmajor histocompatibility complex, class I, C HLA-DMAmajor histocompatibility complex, class II, DM alpha HLA-DMBmajor histocompatibility complex, class II, DM beta HLA-DOAmajor histocompatibility complex, class II, DO alpha HLA-DOBmajor histocompatibility complex, class II, DO beta HLA-DPA1major histocompatibility complex, class II, DP alpha 1 HLA-DPB1major histocompatibility complex, class II, DP beta 1 HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 HLA-DQA2major histocompatibility complex, class II, DQ alpha 2 HLA-DQB1major histocompatibility complex, class II, DQ beta 1 HLA-DQB2major histocompatibility complex, class II, DQ beta 2 HLA-DQB3major histocompatibility complex, class II, DQ beta 3 HLA-DRAmajor histocompatibility complex, class II, DR alpha HLA-DRB1major histocompatibility complex, class II, DR beta 1 HLA-DRB3major histocompatibility complex, class II, DR beta 3 HLA-DRB4major histocompatibility complex, class II, DR beta 4 HLA-DRB5major histocompatibility complex, class II, DR beta 5 HLA-Emajor histocompatibility complex, class I, E HLA-Fmajor histocompatibility complex, class I, F HLA-Gmajor histocompatibility complex, class I, G HMOX1heme oxygenase 1 ICAM1intercellular adhesion molecule 1 IFNGinterferon gamma IFNGR1interferon gamma receptor 1 IFNGR2interferon gamma receptor 2 IHHIndian hedgehog signaling molecule IKBKBinhibitor of nuclear factor kappa B kinase subunit beta IKBKEinhibitor of nuclear factor kappa B kinase subunit epsilon IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma IL10interleukin 10 IL10RAinterleukin 10 receptor subunit alpha IL10RBinterleukin 10 receptor subunit beta IL18interleukin 18 IL18RAPinterleukin 18 receptor accessory protein IL1Ainterleukin 1 alpha IL1Binterleukin 1 beta IL1F10interleukin 1 family member 10 IL1R1interleukin 1 receptor type 1 IL1R2interleukin 1 receptor type 2 IL1RAPinterleukin 1 receptor accessory protein IL1RAPL1interleukin 1 receptor accessory protein like 1 IL1RAPL2interleukin 1 receptor accessory protein like 2 IL1RL1interleukin 1 receptor like 1 IL1RL2interleukin 1 receptor like 2 IL1RNinterleukin 1 receptor antagonist IL33interleukin 33 IL36Ainterleukin 36 alpha IL36Binterleukin 36 beta IL36Ginterleukin 36 gamma IL36RNinterleukin 36 receptor antagonist IL37interleukin 37 IL4Rinterleukin 4 receptor IL6interleukin 6 IL6Rinterleukin 6 receptor IL6STinterleukin 6 signal transducer INPP5Dinositol polyphosphate-5-phosphatase D JAK1Janus kinase 1 JUNJun proto-oncogene, AP-1 transcription factor subunit MAFMAF bZIP transcription factor MAFBMAF bZIP transcription factor B MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K6mitogen-activated protein kinase kinase 6 MAP3K14mitogen-activated protein kinase kinase kinase 14 MAP3K7mitogen-activated protein kinase kinase kinase 7 MAP4K4mitogen-activated protein kinase kinase kinase kinase 4 MAPK1mitogen-activated protein kinase 1 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK8mitogen-activated protein kinase 8 MIR155microRNA 155 MTORmechanistic target of rapamycin kinase NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NFKBIANFKB inhibitor alpha NFKBIBNFKB inhibitor beta NFKBIDNFKB inhibitor delta NFKBIENFKB inhibitor epsilon NOS2nitric oxide synthase 2 PBX1PBX homeobox 1 PKMpyruvate kinase M1/2 PRDM1PR/SET domain 1 PRKAA1protein kinase AMP-activated catalytic subunit alpha 1 PRKAA2protein kinase AMP-activated catalytic subunit alpha 2 PRKAB1protein kinase AMP-activated non-catalytic subunit beta 1 PRKAB2protein kinase AMP-activated non-catalytic subunit beta 2 PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 PRKAG3protein kinase AMP-activated non-catalytic subunit gamma 3 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit SIRT1sirtuin 1 SOCS3suppressor of cytokine signaling 3 SP1Sp1 transcription factor STAT1signal transducer and activator of transcription 1 STAT3signal transducer and activator of transcription 3 STAT5Asignal transducer and activator of transcription 5A STAT5Bsignal transducer and activator of transcription 5B TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TLR4toll like receptor 4 TNFtumor necrosis factor TRAF6TNF receptor associated factor 6 TYK2tyrosine kinase 2 UCP1uncoupling protein 1
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