Target List
Covers all exons in all known transcripts of targeted genes based on the Human GRCh38 genome build
Carcinomas
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CDK4, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), ESR1 (ERα), FANCL, KIT (CD117), KRAS, MET, MLH1, MLH3, MSH2, MSH3, MSH6, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, RAD51B, RAD51C, RAD51D, RAD54L
Ductal Carcinomas
AR, CCND1, CDH1 (E-Cadherin), CYP2D6, FANCD2, FBXW7, FGFR1, FGFR2, MRE11, MYC, NBN, NTRK3, PPM1D, PPP2R1A, RB1CC1, SF3B1, SLC22A18, STK11 (LKB1), TP53 (p53)
ER-Positive Carcinomas
CDH1 (E-Cadherin), RB1CC1, SF3B1
HER-Positive Carcinomas
AR, CCND1, FANCD2, NTRK3, PPM1D, RB1CC1
Metastatic Breast Cancers
AKT1, BRCA1, BRCA2, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), MDM2, NF1, PALB2, PIK3CA (p110-alpha), PTEN
Mismatch Repair (MMR) Genes
MLH1, MSH2, MSH6, PMS2