Target List
Immediate-Early Response Genes (IEGs)
ARC, BDNF, CEBPB, CEBPD, CREB1, CREM, EGR1, EGR2, EGR3, EGR4, FOS, HOMER1, JUN, JUNB, KLF10, MMP9, NFKB1, NFKBIB (TRIP9), NGF, NPTX2, NR4A1 (NUR77), NTF3, PCDH8, PIM1, PLAT (TPA), RELA, RGS2, RHEB, SRF, TNF
Late Response in Synaptic Plasticity
INHBA, SYNPO
Long Term Potentiation (LTP)
ADCY1, ADCY8, BDNF, CAMK2A, CAMK2G, CDH2 (N-Cadherin), CNR1, GABRA5, GNAI1, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1 (ERK2), MMP9, NTF4, NTRK2, PLCG1, PPP1CA, PPP1CC, PPP3CA, PRKCA, PRKCG, RAB3A, YWHAQ (14-3-3θ)
Long Term Depression (LTD)
GNAI1, GRIA1, GRIA2, GRIA3, GRIA4, GRIP1, GRM1, GRM2, IGF1, MAPK1 (ERK2), NOS1 (nNOS), NGFR, PICK1, PLAT (TPA), PPP1CA, PPP1CC, PPP1R14A (CPI-17), PPP2CA, PPP3CA, PRKCA, PRKG1
Cell Adhesion Molecules
ADAM10, CDH2 (N-Cadherin), GRIN2A, GRIN2B, NCAM1, PCDH8, PPP2CA, RELN, TNF
Extracellular Matrix (ECM) Molecules
ADAM10, MMP9, PLAT (TPA), RELN, TIMP1
CREB Cofactors
AKT1, CAMK2G, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, MAPK1 (ERK2), PPP1CA, PPP1CC
Neuronal Receptors
EPHB2, GABRA5, GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8, NTRK2
Postsynaptic Density (PSD)
ADAM10, ARC, DLG4 (PSD95), GRIA1, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRM1, GRM3, HOMER1, PICK1, SYNPO
Other Synaptic Plasticity Genes
KIF17, SIRT1