Target List
Skeletal Muscle Contractility
Dystrophin-Glycoprotein Complex
CAMK2G, CAPN3, CAV3, DAG1, DMD (Dystrophin), DYSF, EMD, LMNA, MAPK1 (ERK2), SGCA
Titin Complex
ACTA1, ACTN3, CAPN3, CRYAB, DES, LMNA, TTN, LOC704095 (TNNT3), LOC721041 (TNNI2), MAPK1 (ERK2), MSTN (GDF8), MYH1, MYH2, MYOT, NEB, SGCA, TNNT1, TRIM63 (MuRF1)
Energy Metabolism
HK2, LOC709604 (CS), PDK4, SLC2A4 (GLUT4)
Fast-Twitch Fibers
ATP2A1, LOC721041 (TNNI2), LOC704095 (TNNT3), MYH1, MYH2
Slow-Twitch Fibers
LOC697047 (TNNC1), MB, MYH1, TNNT1
Other Skeletal Muscle Contractility Genes
DMPK, IKBKB (IKKβ), RPS6KB1
Skeletal Myogenesis
ACTA1, ADRB2, AGRN, BMP4, CAPN2, CAST, CAV1, CTNNB1, DMD (Dystrophin), HDAC5, IGF1, IGFBP3, IGFBP5, LOC702013 (PAX7), RHOA (RHOA), MBNL1, MEF2C, MSTN (GDF8), MUSK, MYF5, MYF6, MYOD1, MYOG, PAX3, PPP3CA, RPS6KB1, UTRN
Skeletal Muscle Hypertrophy
ACTA1, ACVR2B, ADRB2, IGF1, IGFBP5, MSTN (GDF8), MYF6, MYOD1, RPS6KB1
Skeletal Muscle Autocrine Signaling
ADIPOQ, FGF2, IGF1, IL6, LEP, MSTN (GDF8), TGFB1
Diabetes / Metabolic Syndrome
ADIPOQ, LEP, LOC711027 (PPARGC1B, PGC-1β), PPARG, PPARGC1A (PGC-1α), PRKAA1 (AMPK), PRKAB2, PRKAG1, PRKAG3, SLC2A4 (GLUT4)
Skeletal Muscle Wasting / Atrophy
Autophagy
CAPN2, CASP3, FBXO32 (Atrogin-1), FOXO1, FOXO3, LOC711027 (PPARGC1B, PGC-1β), MSTN (GDF8), NOS2 (iNOS), PPARGC1A (PGC-1α), RPS6KB1, TRIM63 (MuRF1)
Dystrophy
AKT1, AKT2, FBXO32 (Atrogin-1), IL1B, LOC718976 (MAPK14, p38ALPHA), LOC718976 (MAPK14, p38ALPHA), MAPK1 (ERK2), MAPK3 (ERK1), MAPK8 (JNK1), MMP9, NFKB1, TNF, TRIM63 (MuRF1), UTRN