IGF-1 Signaling
Insulin-like growth factor-1 (IGF-1) is a peptide hormone under control of the growth hormone. IGF-1 promotes cell proliferation, growth and survival. Six specific binding proteins, IGFBP 1-6, allow for a more nuanced control of IGF activity....
Pathway Summary
Insulin-like growth factor-1 (IGF-1) is a peptide hormone under control of the growth hormone. IGF-1 promotes cell proliferation, growth and survival. Six specific binding proteins, IGFBP 1-6, allow for a more nuanced control of IGF activity.The IGF-1 receptor (IGF-1R) is a transmembrane tyrosine kinase protein. IGF-1-induced receptor activation results in autophosphorylation followed by an enhanced capability to activate downstream pathways. Activated IGF-1R phosphorylates SHC and IRS-1. SHC along with adapter molecules GRB2 and SOS forms a signaling complex that activates the Ras/Raf/MEK/ERK pathway. ERK translocation to the nucleus results in the activation of transcriptional regulators ELK-1, c-Jun and c-Fos which induce genes that promote cell growth and differentiation. IRS-1 activates pathways for cell survival via the PI3K/PDK1/AKT/BAD pathway. IRS-1 also activates pathways for cell growth via the PI3K/PDK1/p70RSK pathway. IGF-1 also signals via the JAK/STAT pathway by inducing tyrosine phosphorylation of JAK-1, JAK-2 and STAT-3. SOCS proteins are able to inhibit the JAKs thereby inhibiting this pathway.The adapter protein GRB10 interacts with IGF-IR. GRB10 also binds the E3 ubiquitin ligase NEDD4 and promotes ligand stimulated ubiquitination, internalization, and degradation of the IGF-IR as a means of long-term attenuation of signaling.
IGF-1 Signaling Genes list
Explore Genes related to IGF-1 Signaling
AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 BADBCL2 associated agonist of cell death CASP9caspase 9 CCN1cellular communication network factor 1 CCN2cellular communication network factor 2 CCN3cellular communication network factor 3 CSNK2A1casein kinase 2 alpha 1 CSNK2A2casein kinase 2 alpha 2 CSNK2A3casein kinase 2 alpha 3 CSNK2Bcasein kinase 2 beta ELK1ETS transcription factor ELK1 ERASES cell expressed Ras FOSFos proto-oncogene, AP-1 transcription factor subunit FOXO1forkhead box O1 FOXO3forkhead box O3 GRB10growth factor receptor bound protein 10 GRB2growth factor receptor bound protein 2 HRASHRas proto-oncogene, GTPase IGF1insulin like growth factor 1 IGF1Rinsulin like growth factor 1 receptor IGFBP1insulin like growth factor binding protein 1 IGFBP2insulin like growth factor binding protein 2 IGFBP3insulin like growth factor binding protein 3 IGFBP4insulin like growth factor binding protein 4 IGFBP5insulin like growth factor binding protein 5 IGFBP6insulin like growth factor binding protein 6 IGFBP7insulin like growth factor binding protein 7 IRS1insulin receptor substrate 1 IRS2insulin receptor substrate 2 JAK1Janus kinase 1 JAK2Janus kinase 2 JUNJun proto-oncogene, AP-1 transcription factor subunit KRASKRAS proto-oncogene, GTPase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPK8mitogen-activated protein kinase 8 MRASmuscle RAS oncogene homolog NEDD4NEDD4 E3 ubiquitin protein ligase NRASNRAS proto-oncogene, GTPase PDPK13-phosphoinositide dependent protein kinase 1 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PRKACAprotein kinase cAMP-activated catalytic subunit alpha PRKACBprotein kinase cAMP-activated catalytic subunit beta PRKACGprotein kinase cAMP-activated catalytic subunit gamma PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha PRKAR2Bprotein kinase cAMP-dependent type II regulatory subunit beta PRKCIprotein kinase C iota PRKCZprotein kinase C zeta PTK2protein tyrosine kinase 2 PTPN11protein tyrosine phosphatase non-receptor type 11 PXNpaxillin RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASA1RAS p21 protein activator 1 RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RPS6KB1ribosomal protein S6 kinase B1 RPS6KB2ribosomal protein S6 kinase B2 RRASRAS related RRAS2RAS related 2 SFNstratifin SHC1SHC adaptor protein 1 SOCS1suppressor of cytokine signaling 1 SOCS2suppressor of cytokine signaling 2 SOCS3suppressor of cytokine signaling 3 SOCS4suppressor of cytokine signaling 4 SOCS5suppressor of cytokine signaling 5 SOCS6suppressor of cytokine signaling 6 SOCS7suppressor of cytokine signaling 7 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 SRFserum response factor STAT3signal transducer and activator of transcription 3 YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta