Target List
Drug Transporters
Metallothioneins
MT2A, MT3
P-Glycoprotein Family Members
ABCB1 (MDR1, PGY1), ABCC1 (MRP1), GPI
Phase I Metabolizing Enzymes
CYP11B2, CYP17A1, CYP19A1, CYP1A1, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5
Phase II Metabolizing Enzymes
Carboxylesterases
CES1, CES2, CES3
Decarboxylases
GAD1, GAD2
Dehydrogenases
ADH1B, ADH1C, ADH4, ADH5, ADH6, ALAD, ALDH1A1 (RALDH1), HSD17B1, HSD17B2, HSD17B3
Glutathione Peroxidases (GPx)
GPX1, GPX2, GPX3, GPX4, GPX5, GSTA3, GSTA4, GSTM2, GSTM3, GSTM5, GSTP1, GSTT1, GSTZ1, LPO, MPO
Lipoxygenases
ALOX12, ALOX15, ALOX5, APOE
Hydrolases
ASNA1, EPHX1, FAAH, FBP1
Kinases
HK2, PKLR, PKM
Oxidoreductases
AOC1, BLVRA, BLVRB, CYB5R3, GPX1, GPX2, GSR, MTHFR, NOS3 (eNOS), NQO1, SRD5A1, SRD5A2
Paraoxonases
PON1, PON2, PON3
Glutathione S-Transferases
GSTA3, GSTA4, GSTM2, GSTM3, GSTM5, GSTP1, GSTT1, MGST1, MGST2, MGST3
Other Phase II Metabolizing Enzymes
CHST1, NAT1, NAT2, COMT
Other Drug Metabolism Genes
AHR, ARNT, GCKR, SNN