Dusp26 Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; p53 binding activity; and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP26 (dual specificity phosphatase 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp26 |
| Official Name | dual specificity phosphatase 26 [Source:RGD Symbol;Acc:1310090] |
| Ensembl ID | ENSRNOG00000011518 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 26 |
| Synonyms | 2310043K02Rik, DSP-4, dual specificity phosphatase 26, DUSP24, LDP-4, MKP-8, NATA1, NEAP, RGD1310090, SKRP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein tyrosine/serine/threonine phosphatase
- protein phosphatase
- transcription factor binding
- enzyme
- p53 binding
- protein binding
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of MAPK cascade
- negative regulation of ERK1 and ERK2 cascade
- protein dephosphorylation
- positive regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- p53 binding
- MAP kinase phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity