TLE1 Gene Summary [Human]
Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TLE1 |
| Official Name | TLE family member 1, transcriptional corepressor [Source:HGNC Symbol;Acc:HGNC:11837] |
| Ensembl ID | ENSG00000196781 |
| Bio databases IDs | |
| Aliases | TLE family member 1, transcriptional corepressor, enhancer of split groucho 1 |
| Synonyms | ESG, ESG1, GRG1, GROUCHO 1, TLE family member 1, transcriptional corepressor, transducin-like enhancer of split 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TLE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- transcription regulator
- WD40 repeats
- Groucho/TLE N-terminal Q-rich domain
- transcription co-repressor
- WD domain, G-beta repeat
- transcription factor binding
- WD40
- chromatin binding
- protein binding
- glutamine-rich domain
- identical protein binding
Pathways
Biological processes and signaling networks where the TLE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- chronic obstructive pulmonary disease
- androgenic alopecia
- immunological disorder
- endometrial carcinoma
- epithelial endometrial cancer
- dental disorder
role in cell
- expression in
- growth
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TLE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of anoikis
- negative regulation of transcription, DNA-dependent
- signal transduction
- positive regulation of gene expression
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription corepressor activity