Satb1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and chromatin binding activity. Acts upstream of or within several processes, including T cell activation; negative regulation of transcription by RNA polymerase II; and reflex. Located in heterochromatin and nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human SATB1 (SATB homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Satb1 |
| Official Name | special AT-rich sequence binding protein 1 [Source:MGI Symbol;Acc:MGI:105084] |
| Ensembl ID | ENSMUSG00000023927 |
| Bio databases IDs | |
| Aliases | special AT-rich sequence binding protein 1 |
| Synonyms | 2610306G12Rik, DEFDA, DHDBV, KTZSL, SATB homeobox 1, special AT-rich sequence binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Satb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- dimerization domain
- CUT1-like DNA-binding domain of SATB
- DNA binding domain
- N-terminal domain of SATB1 and similar proteins
- PDZ-like domain
- nucleic acid binding
- CR2 domain
- transcription factor binding
- chromatin binding
- protein binding
- MAR binding domain
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- CUT domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- homeodomain
- transcription factor activity
- nuclear matrix targeting site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- breast carcinoma
- developmental delay with dysmorphic facies and dental anomalies
- Kohlschutter-Tonz syndrome-like
- chronic mucus hypersecretion
- Sjögren syndrome
- habitual abortion
- Sézary syndrome
- Parkinson disease
- lung adenocarcinoma
role in cell
- proliferation
- expression in
- cell death
- activation in
- growth
- apoptosis
- quantity
- number
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatin
- interchromatin space
- nucleoplasm
- nuclear bodies
- nuclear matrix
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Satb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity