Ikbkg Gene Summary [Mouse]
Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and signaling adaptor activity. Involved in several processes, including anoikis; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and positive regulation of metabolic process. Acts upstream of or within B cell homeostasis; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of canonical NF-kappaB signal transduction. Located in cytoplasm. Part of IkappaB kinase complex. Is expressed in early conceptus; genitourinary system; and musculature. Used to study Bloch-Sulzberger syndrome and steatotic liver disease. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; X-linked recessive disease (multiple); learning disability; and liver cancer. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikbkg |
| Official Name | inhibitor of kappaB kinase gamma [Source:MGI Symbol;Acc:MGI:1338074] |
| Ensembl ID | ENSMUSG00000004221 |
| Bio databases IDs | |
| Aliases | inhibitor of kappaB kinase gamma |
| Synonyms | 1110037D23Rik, AMCBX1, EDAID1, FIP-3, Fip3p, I Kappa B Gamma, IKBK3, IkB γ, IKK3, IKKAP1, IKKG, IKK[g], IKK-gamma, IKK-γ, IMD33, inhibitor of kappaB kinase gamma, inhibitor of kappaB kinase γ, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma, inhibitor of nuclear factor κ B kinase regulatory subunit γ, IP, IP1, IP2, IPD2, I κ B γ, NEMO, NEMO RELATED, SAIDX, ZC2HC9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ikbkg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2H2 type zinc-finger
- NEMO ubiquitin-binding domain
- protein binding activity, bridging
- coiled-coil domain
- leucine zipper domain
- identical protein binding
- NF-kappa-B essential modulator NEMO
- proline rich domain
- leucine-rich repeat
- peroxisome proliferator activated receptor binding
- ubiquitin binding domain
- Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
- IKK binding domain
- ubiquitin protein ligase binding
- leucine rich domain
- IKK alpha/beta binding domain
- UBAN motif
- alpha helix
- ubiquitin binding
- protein domain specific binding
- protein binding
- receptor binding
- phosphorylation site
- kinase
- NEMO-binding domain
- binding protein
- Tank binding domain
- protein homodimerization
- zinc finger domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Ikbkg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Phase Response Signaling
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- Apoptosis Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- CD27 Signaling in Lymphocytes
- CD28 Signaling in T Helper Cells
- CD40 Signaling
- Chronic Myeloid Leukemia Signaling
- Death Receptor Signaling
- Dendritic Cell Maturation
- G-Protein Coupled Receptor Signaling
- Glucocorticoid Receptor Signaling
- Gα12/13 Signaling
- Gαq Signaling
- Hepatic Cholestasis
- HER-2 Signaling in Breast Cancer
- NF-κB Signaling
- PEDF Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- experimental autoimmune encephalomyelitis
- anhidrotic ectodermal dysplasia with immune deficiency
- hereditary disorder
phenotypes
- abnormal bone marrow cell morphology/development
- abnormal chemokine secretion
- abnormal dermal pigmentation
- abnormal epidermal pigmentation
- abnormal epidermis stratum basale morphology
- abnormal epidermis suprabasal layer morphology
- abnormal fertility/fecundity
- abnormal humoral immune response
- abnormal keratinocyte morphology
- abnormal liver morphology
- abnormal locomotor behavior
- absent megakaryocytes
- absent subcutaneous adipose tissue
- azoospermia
- decreased B cell number
- decreased body weight
- decreased interleukin-12b secretion
- decreased interleukin-6 secretion
- decreased regulatory T cell number
- decreased susceptibility to endotoxin shock
- decreased tumor necrosis factor secretion
- embryonic lethality during organogenesis complete penetrance
- enlarged spleen
- erythroderma
- hyperkeratosis
- increased apoptosis
- increased fibroblast apoptosis
- increased hepatocyte apoptosis
- increased interleukin-6 secretion
- increased keratinocyte apoptosis
- liver hemorrhage
- no abnormal phenotype detected
- parakeratosis
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- prenatal lethality complete penetrance
- preweaning lethality complete penetrance
- reduced female fertility
- retarded hair growth
- scaly skin
- skin inflammation
- small spleen
- small thymus
- sparse hair
- spontaneous skin ulceration
- thick epidermis
- tremors
role in cell
- production in
- expression in
- apoptosis
- phosphorylation in
- cell death
- quantity
- activation in
- formation
- formation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- insoluble fractions
- cytoplasmic fiber
- Cytoplasm
- perinuclear region
- Mitochondria
- immunological synapses
- cytoplasmic particles
- granules
- cytosol
- nucleoplasm
- spindle pole
- membrane rafts
- mitotic spindle
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ikbkg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- macromolecular complex assembly
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- anoikis
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- I-kappaB kinase/NF-kappaB cascade
- response to virus
- positive regulation of NF-kappaB transcription factor activity
- defense response to bacterium
- positive regulation of T cell receptor signaling pathway
- inflammatory response
- immune response
- establishment of vesicle localization
- innate immune response
- apoptotic process
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- mitotic spindle
- cytoplasm
- IkappaB kinase complex
- spindle pole
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- K63-linked polyubiquitin binding
- polyubiquitin binding
- signaling adaptor activity
- metal ion binding
- protein heterodimerization activity