Fgf10 Gene Summary [Mouse]
Enables chemoattractant activity. Involved in positive regulation of DNA-templated transcription and radial glial cell differentiation. Acts upstream of or within several processes, including gland morphogenesis; lung development; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study intestinal atresia and lacrimoauriculodentodigital syndrome 1. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf10 |
| Official Name | fibroblast growth factor 10 [Source:MGI Symbol;Acc:MGI:1099809] |
| Ensembl ID | ENSMUSG00000021732 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 10 |
| Synonyms | AEY17, Fgf5a, fibroblast growth factor 10, Gsfaey17, LADD3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- chemoattractant
- protein binding
- fibroblast growth factor receptor binding
- heparin binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- rheumatoid arthritis
- prostate cancer
- Alzheimer disease
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
- non-small cell lung cancer
phenotypes
- decreased grip strength
- decreased lean body mass
- increased circulating HDL cholesterol level
- increased circulating cholesterol level
- increased total body fat amount
- preweaning lethality complete penetrance
- Harderian gland atrophy
- abnormal Rathke's pouch apoptosis
- abnormal Wolffian duct morphology
- abnormal adipose tissue morphology
- abnormal branching involved in trachea morphogenesis
- abnormal branching of the mammary ductal tree
- abnormal cecum development
- abnormal cochlea morphology
- abnormal colon morphology
- abnormal crista ampullaris morphology
- abnormal ear morphology
- abnormal embryo development
- abnormal embryonic tissue morphology
- abnormal enzyme/coenzyme activity
- abnormal epidermal layer morphology
- abnormal forced expiratory flow rates
- abnormal gastric chief cell morphology
- abnormal grip strength
- abnormal hair follicle morphology
- abnormal hair shaft morphology
- abnormal heart atrium auricular region morphology
- abnormal heart position or orientation
- abnormal hindgut morphology
- abnormal hypaxial muscle morphology
- abnormal incisor morphology
- abnormal inner ear canal morphology
- abnormal inner ear morphology
- abnormal inner ear vestibule morphology
- abnormal intestinal epithelium morphology
- abnormal kidney inner medulla morphology
- abnormal kidney medulla morphology
- abnormal kidney outer medulla morphology
- abnormal large intestine crypts of Lieberkuhn morphology
- abnormal lateral nasal gland morphology
- abnormal lens epithelium morphology
- abnormal lens fiber morphology
- abnormal lens morphology
- abnormal limb bud morphology
- abnormal limb development
- abnormal lung development
- abnormal male reproductive system morphology
- abnormal mammary fat pad morphology
- abnormal mammary placode morphology
- abnormal metanephric ureteric bud development
- abnormal nasal gland morphology
- abnormal neurohypophysis development
- abnormal palate morphology
- abnormal pelvic girdle bone morphology
- abnormal periderm development
- abnormal primitive urogenital sinus morphology
- abnormal prostate gland morphology
- abnormal pulmonary circulation
- abnormal pulmonary elastic fiber morphology
- abnormal pulmonary trunk morphology
- abnormal respiratory system morphology
- abnormal retinal apoptosis
- abnormal scapula morphology
- abnormal secondary palate development
- abnormal sensory neuron innervation pattern
- abnormal stomach submucosa morphology
- abnormal submandibular duct morphology
- abnormal tongue morphology
- abnormal tooth morphology
- abnormal urethra morphology
- abnormal utricle morphology
- abnormal vestibular hair cell kinocilium morphology
- abnormal vestibular hair cell stereociliary bundle morphology
- absent Harderian gland
- absent Rathke's pouch
- absent adenohypophysis
- absent bulbourethral gland
- absent colon
- absent forelimb
- absent hindlimb
- absent humerus
- absent lacrimal glands
- absent limb buds
- absent limbs
- absent lung buds
- absent lungs
- absent palatal rugae
- absent pituitary gland
- absent posterior semicircular canal
- absent prostate gland
- absent pulmonary artery
- absent pulmonary vein
- absent radius
- absent rectum
- absent salivary gland
- absent seminal vesicle
- absent submandibular gland
- absent superior semicircular canal
- absent thyroid gland
- absent ulna
- cecal atresia
- cleft secondary palate
- decreased body weight
- decreased colon length
- decreased fetal size
- decreased hair follicle number
- decreased lateral semicircular canal size
- decreased palatal length
- decreased pancreatic beta cell number
- decreased trachea gland number
- dextrocardia
- diaphragmatic hernia
- dilated kidney calyx
- epididymal cyst
- eyelids open at birth
- hypospadia
- impaired branching involved in bronchus morphogenesis
- impaired branching involved in preterminal bronchiole morphogenesis
- impaired lung alveolus development
- increased hair follicle apoptosis
- microphthalmia
- narrow eye opening
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- palatal shelf fusion with tongue or mandible
- pancreas fibrosis
- perinatal lethality complete penetrance
- prenatal lethality complete penetrance
- short incisors
- small ears
- small hair follicle bulb
- small kidney
- small lung
- small molars
- small otic capsule
- small pancreas
- small stomach
- small thymus
- small vestibular saccule
- submandibular gland hypoplasia
- thin epidermis
- thin skin
- tongue ankylosis
- translucent skin
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- binding in
- degradation in
- differentiation
- quantity
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Ras protein signal transduction
- branching morphogenesis of a tube
- regulation of smoothened signaling pathway
- urothelial cell proliferation
- epithelial cell proliferation
- positive regulation of lymphocyte proliferation
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- mesonephros development
- positive regulation of epithelial cell proliferation
- positive regulation of urothelial cell proliferation
- male genitalia morphogenesis
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- female genitalia morphogenesis
- embryonic camera-type eye development
- semicircular canal fusion
- Type II pneumocyte differentiation
- prostatic bud formation
- vascular endothelial growth factor receptor signaling pathway
- embryonic genitalia morphogenesis
- metanephros morphogenesis
- negative regulation of stem cell proliferation
- mesenchymal cell differentiation involved in lung development
- positive regulation of stem cell proliferation
- hair follicle morphogenesis
- submandibular salivary gland formation
- positive regulation of cell proliferation
- spleen development
- lung epithelium development
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of transcription from RNA polymerase II promoter
- lung proximal/distal axis specification
- epithelial cell proliferation involved in salivary gland morphogenesis
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
- regulation of saliva secretion
- thymus development
- branch elongation involved in salivary gland morphogenesis
- fibroblast proliferation
- smooth muscle cell differentiation
- angiogenesis
- white fat cell proliferation
- positive regulation of fibroblast proliferation
- stem cell proliferation
- somatic stem cell maintenance
- positive regulation of keratinocyte migration
- positive regulation of epithelial cell migration
- positive regulation of peptidyl-tyrosine phosphorylation
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- mesenchymal-epithelial cell signaling involved in lung development
- positive regulation of ATPase activity
- radial glial cell differentiation
- positive regulation of MAPK cascade
- determination of left/right symmetry
- thyroid gland development
- metanephros development
- otic vesicle formation
- positive regulation of protein phosphorylation
- endothelial cell proliferation
- response to lipopolysaccharide
- positive regulation of endothelial cell proliferation
- protein localization at cell surface
- positive chemotaxis
- muscle cell fate commitment
- bud elongation involved in lung branching
- fibroblast growth factor receptor signaling pathway
- embryonic digestive tract morphogenesis
- bud outgrowth involved in lung branching
- white fat cell differentiation
- regulation of activin receptor signaling pathway
- wound healing
- lacrimal gland development
- Wnt receptor signaling pathway
- positive regulation of hair follicle cell proliferation
- positive regulation of DNA repair
- lung saccule development
- embryonic pattern specification
- positive regulation of canonical Wnt receptor signaling pathway
- bronchiole morphogenesis
- pituitary gland development
- organ morphogenesis
- tear secretion
- negative regulation of epithelial cell differentiation
- positive regulation of gene expression
- positive regulation of white fat cell proliferation
- organ induction
- response to estradiol stimulus
- regulation of cell migration
- secretion by lung epithelial cell involved in lung growth
- odontogenesis of dentin-containing tooth
- salivary gland development
- positive regulation of Notch signaling pathway
- positive regulation of keratinocyte proliferation
- Harderian gland development
- induction of positive chemotaxis
- pancreas development
- keratinocyte proliferation
- positive regulation of G1/S transition of mitotic cell cycle
- limb bud formation
- positive regulation of epithelial cell proliferation involved in wound healing
- mammary gland bud formation
- tissue regeneration
- ERK1 and ERK2 cascade
- establishment of mitotic spindle orientation
- blood vessel remodeling
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- chemoattractant activity
- heparin binding
- type 2 fibroblast growth factor receptor binding
- fibroblast growth factor receptor binding