Tal1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tal1 |
| Official Name | T cell acute lymphocytic leukemia 1 [Source:MGI Symbol;Acc:MGI:98480] |
| Ensembl ID | ENSMUSG00000028717 |
| Bio databases IDs | |
| Aliases | T cell acute lymphocytic leukemia 1 |
| Synonyms | bHLHa17, Hpt, SCL, SCL/tal-1, TAL-1/SCL, TAL bHLH transcription factor 1, erythroid differentiation factor, T cell acute lymphocytic leukaemia 1, T cell acute lymphocytic leukemia 1, TCL5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tal1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- thymus cancer
- lymphoid cancer
- mediastinal cancer
- lymphatic neoplasia
- lymphomagenesis
- thoracic cancer
- hematologic cancer
- hematological neoplasia
- severe acute respiratory syndrome
phenotypes
- abnormal blood vessel morphology
- abnormal bone marrow cell morphology/development
- abnormal coat appearance
- abnormal ectoderm development
- abnormal embryonic erythropoiesis
- abnormal embryonic hematopoiesis
- abnormal erythroid progenitor cell morphology
- abnormal erythropoiesis
- abnormal hair follicle development
- abnormal hair growth
- abnormal heart development
- abnormal kidney morphology
- abnormal placental labyrinth vasculature morphology
- abnormal podocyte foot process morphology
- abnormal renal glomerulus morphology
- abnormal skin pigmentation
- abnormal vein morphology
- absent common myeloid progenitor cells
- absent visceral yolk sac blood islands
- absent vitelline blood vessels
- alopecia
- anemia
- anisocytosis
- decreased body size
- decreased embryo size
- decreased hair follicle number
- decreased hematocrit
- decreased hemoglobin content
- decreased leukocyte cell number
- decreased mean corpuscular hemoglobin concentration
- decreased mean corpuscular volume
- decreased survivor rate
- delayed heart looping
- dilated dorsal aorta
- disorganized yolk sac vascular plexus
- distended pericardium
- embryo tissue necrosis
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality
- embryonic lethality between implantation and somite formation complete penetrance
- embryonic lethality during organogenesis complete penetrance
- enlarged heart
- extramedullary hematopoiesis
- focal hair loss
- fused podocyte foot processes
- glomerulosclerosis
- heart left ventricle hypertrophy
- hypertension
- hypoxia
- incomplete embryo turning
- incomplete somite formation
- increased hematopoietic stem cell number
- increased neuron apoptosis
- increased red blood cell distribution width
- increased spleen weight
- kidney failure
- lethality throughout fetal growth and development incomplete penetrance
- microcytic anemia
- pale yolk sac
- pallor
- pericardial edema
- skin edema
- sparse hair
role in cell
- expression in
- activation in
- formation
- cell viability
- apoptosis
- survival
- cell cycle progression
- lack
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tal1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic hemopoiesis
- hemopoiesis
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- erythrocyte maturation
- negative regulation of transcription from RNA polymerase II promoter
- locomotory behavior
- positive regulation of cell division
- positive regulation of transcription, DNA-dependent
- angiogenesis
- platelet formation
- megakaryocyte development
- basophil differentiation
- positive regulation of protein complex assembly
- regulation of mast cell differentiation
- spinal cord association neuron differentiation
- hemangioblast cell differentiation
- hemopoietic stem cell differentiation
- regulation of cell proliferation
- positive regulation of mitotic cell cycle
- astrocyte fate commitment
- definitive hemopoiesis
- regulation of transcription from RNA polymerase II promoter
- megakaryocyte differentiation
- erythrocyte differentiation
- cell fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- chromatin binding
- enzyme binding
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity