Il2rg Gene Summary [Mouse]
This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Details
| Type | Protein Coding |
| Official Symbol | Il2rg |
| Official Name | interleukin 2 receptor, gamma chain [Source:MGI Symbol;Acc:MGI:96551] |
| Ensembl ID | ENSMUSG00000031304 |
| Bio databases IDs | |
| Aliases | interleukin 2 receptor, gamma chain |
| Synonyms | Ab2-183, CD132, Cgamma chain, CIDX, common cytokine receptor γ chain, Common Gamma Chain Receptor, Common γ Chain, Common γ Chain Receptor, Cr gamma, Cr γ, CYTOKINE receptor COMMON gamma CHAIN, CYTOKINE receptor COMMON γ CHAIN, Cγ chain, gamma(c), gc, [g]c, IL-12R gamma, IL-12R γ, IL15RG, IL-2/15R gamma, IL-2/15R γ, Il-2 receptor γ c, IL2R gamma, IL2R γ, IL7 Rgamma, IMD4, interleukin 2 receptor, gamma chain, interleukin 2 receptor subunit gamma, interleukin 2 receptor subunit γ, interleukin 2 receptor, γ chain, P64, SCIDX, SCIDX1, γ C, γ(c), γ chain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il2rg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-4 receptor
- interleukin-7 receptor
- protein binding
- Fibronectin type 3 domain
- proline tyrosine motif
- interleukin-2 receptor
- interleukin-2 binding
- PEST domain
- cytoplasmic domain
- FN3
- interleukin-15 receptor
- transmembrane domain
- intracellular domain
- membrane-proximal domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Il2rg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Crosstalk between Dendritic Cells and Natural Killer Cells
- FAK Signaling
- Glucocorticoid Receptor Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-15 Signaling
- IL-2 Signaling
- IL-4 Signaling
- IL-7 Signaling Pathway
- IL-9 Signaling
- Molecular Mechanisms of Cancer
- p70S6K Signaling
- Primary Immunodeficiency Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- STAT3 Pathway
- T Helper Cell Differentiation
- Telomerase Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- metastasis
- diabetic nephropathy
- fibrosis
- non-Hodgkin lymphoma
- acute myeloid leukemia
- X-linked severe combined immunodeficiency
- cutaneous melanoma
- M7 childhood acute myeloid leukemia
- high risk neuroblastoma
phenotypes
- abnormal B cell number
- abnormal CD4-positive alpha beta T cell morphology
- abnormal alpha-beta intraepithelial T cell morphology
- abnormal basophil physiology
- abnormal cecum morphology
- abnormal cell-mediated immunity
- abnormal class switch recombination
- abnormal decidua basalis morphology
- abnormal dendritic cell physiology
- abnormal estrous cycle
- abnormal gamma-delta T cell differentiation
- abnormal gut-associated lymphoid tissue morphology
- abnormal hematopoietic system morphology/development
- abnormal immune serum protein physiology
- abnormal immune system cell morphology
- abnormal immune system organ morphology
- abnormal immunoglobulin level
- abnormal leukocyte morphology
- abnormal lymphocyte morphology
- abnormal mast cell physiology
- abnormal maternal decidual layer morphology
- abnormal mesenteric lymph node morphology
- abnormal myelopoiesis
- abnormal placenta metrial gland morphology
- abnormal proerythroblast morphology
- abnormal splenic cell ratio
- abnormal thymocyte activation
- absent NK cells
- absent Peyer's patches
- absent gamma-delta T cells
- absent gamma-delta intraepithelial T cell
- absent spleen germinal center
- absent spleen white pulp
- absent uterine NK cells
- arrested B cell differentiation
- cecum inflammation
- decreased CD8-positive alpha-beta T cell number
- decreased IgE level
- decreased IgG level
- decreased IgG3 level
- decreased IgM level
- decreased T cell number
- decreased T cell proliferation
- decreased double-negative T cell number
- decreased double-positive T cell number
- decreased immature B cell number
- decreased immunoglobulin level
- decreased interferon-gamma secretion
- decreased interleukin-2 secretion
- decreased interleukin-4 secretion
- decreased lymphocyte cell number
- decreased mature B cell number
- decreased myeloid dendritic cell number
- decreased plasma cell number
- decreased pre-B cell number
- decreased single-positive T cell number
- decreased spleen white pulp amount
- decreased thymocyte number
- enlarged Peyer's patches
- enlarged spleen
- impaired natural killer cell mediated cytotoxicity
- increased macrophage cell number
- increased megakaryocyte cell number
- increased monocyte cell number
- increased neutrophil cell number
- no abnormal phenotype detected
- prolonged diestrus
- prolonged estrous cycle
- prolonged metestrus
- small lymph nodes
- small thymus
- small thymus cortex
- spleen hyperplasia
- spleen hypoplasia
- thymus cortex hypoplasia
- thymus hyperplasia
- thymus hypoplasia
role in cell
- growth
- expression in
- production in
- proliferation
- phosphorylation in
- survival
- loss
- apoptosis
- activation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cell-cell contacts
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- early endosomes
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il2rg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-9-mediated signaling pathway
- cellular homeostasis
- interleukin-4-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- positive regulation of T cell differentiation in thymus
- signal transduction
- T cell differentiation in thymus
- interleukin-7-mediated signaling pathway
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- positive regulation of B cell differentiation
- mature B cell differentiation
- immune response
- cytokine-mediated signaling pathway
- positive regulation of gene expression
- interleukin-15-mediated signaling pathway
- gene expression
- positive regulation of phagocytosis
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- external side of plasma membrane
- cytosol
- endoplasmic reticulum
- receptor complex
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- interleukin-2 receptor activity
- protein binding
- interleukin-4 receptor activity
- interleukin-15 receptor activity
- interleukin-7 receptor activity
- cytokine receptor activity
- cytokine binding
- interleukin-2 binding