Myo6 Gene Summary [Mouse]
Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization; presynaptic modulation of chemical synaptic transmission; and protein localization. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; cochlear hair cell ribbon synapse; and postsynaptic actin cytoskeleton. Is expressed in cerebral cortex ventricular layer; ear; heart; skeletal muscle; and stomach. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo6 |
| Official Name | myosin VI [Source:MGI Symbol;Acc:MGI:104785] |
| Ensembl ID | ENSMUSG00000033577 |
| Bio databases IDs | |
| Aliases | myosin VI |
| Synonyms | BC029719, DFNA22, DFNB37, Myo6<rsv>, Myosin6, Myosin VI, RGD1560646, rsv, sv, TLC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- Myosin and Kinesin motor domain
- ADP binding
- Myosin VI cargo binding domain
- coiled-coil domain
- protein binding
- minimal binding domain
- identical protein binding
- Myosin head (motor domain)
- actin filament binding
- actin binding
- MIU-linker domain found in unconventional myosin-VI
- motor protein
- Myosin
- cargo binding domain
Pathways
Biological processes and signaling networks where the Myo6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- autosomal dominant deafness type 22
- familial nonsyndromic hearing impairment
- hearing loss
- autosomal recessive deafness type 37
- hepatocellular carcinoma
- sporadic age-related sensorineural hearing loss
- lung adenocarcinoma formation
- prostate cancer
phenotypes
- abnormal auditory brainstem response
- abnormal behavior
- abnormal gait
- abnormal startle reflex
- abnormal whole-body plethysmography
- decreased anxiety-related response
- decreased body length
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating amylase level
- decreased circulating glucose level
- decreased circulating triglyceride level
- decreased grip strength
- decreased heart rate
- decreased hemoglobin content
- decreased total body fat amount
- head bobbing
- hyperactivity
- increased lean body mass
- increased vertical activity
- prolonged RR interval
- tremors
- abnormal anxiety-related response
- abnormal auditory brainstem response waveform shape
- abnormal body length
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal cochlear hair cell development
- abnormal cochlear hair cell stereociliary bundle morphology
- abnormal cochlear sensory epithelium morphology
- abnormal crista ampullaris neuroepithelium morphology
- abnormal cuticular plate morphology
- abnormal eye electrophysiology
- abnormal inner ear vestibule morphology
- abnormal inner hair cell stereociliary bundle morphology
- abnormal kinocilium morphology
- abnormal locomotor activation
- abnormal orientation of cochlear hair cell stereociliary bundles
- abnormal orientation of inner hair cell stereociliary bundles
- abnormal orientation of outer hair cell stereociliary bundles
- abnormal otolithic membrane morphology
- abnormal outer hair cell kinocilium morphology
- abnormal placing response
- abnormal reflex
- abnormal vestibular hair cell stereociliary bundle morphology
- abnormal vestibular system physiology
- absent cochlear nerve compound action potential
- absent linear vestibular evoked potential
- absent organ of Corti
- absent pinna reflex
- bidirectional circling
- cardiomyopathy
- circling
- cochlear degeneration
- cochlear ganglion degeneration
- cochlear hair cell degeneration
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
- deafness
- decreased body size
- decreased cochlear hair cell stereocilia number
- decreased inner hair cell stereocilia number
- decreased outer hair cell stereocilia number
- decreased startle reflex
- decreased vestibular hair cell number
- detached tectorial membrane
- fused inner hair cell stereocilia
- fused outer hair cell stereocilia
- fused vestibular hair cell stereocilia
- head shaking
- head tilt
- head tossing
- impaired balance
- impaired hearing
- impaired swimming
- increased heart weight
- increased or absent threshold for auditory brainstem response
- organ of Corti degeneration
- reduced fertility
- reduced linear vestibular evoked potential
- retropulsion
- stereotypic behavior
- stria vascularis degeneration
- utricular macular degeneration
- vestibular ganglion degeneration
- vestibular hair cell degeneration
- vestibular saccular macula degeneration
role in cell
- apoptosis
- accumulation in
- expression in
- aggregation in
- differentiation
- activity
- formation
- number
- cell-cell adhesion
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pericuticular necklace
- glutaminergic synapse
- annular gap junction vesicle
- ruffle
- cytoskeleton
- cilia
- cell periphery
- apical compartment
- perinuclear region
- cellular membrane
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- actin filaments
- cell-cell contacts
- cytoplasmic aggregates
- cytosol
- vesicle membrane
- membrane ruffles
- Golgi membrane
- trans Golgi network
- lysosome membrane
- nucleoplasm
- nuclear envelope
- synapse
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- apical vesicles
- brush border
- microvilli
- perikaryon
- axons
- postsynaptic density
- ribbon synapse
- exosomes
- clathrin-coated vesicles
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- regulation of secretion
- auditory receptor cell differentiation
- inner ear morphogenesis
- DNA damage response, signal transduction by p53 class mediator
- protein localization
- actin filament organization
- response to xenobiotic stimulus
- endocytosis
- intracellular protein transport
- actin filament-based movement
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- autophagic vacuole
- nucleoplasm
- extracellular vesicular exosome
- endosome
- apical part of cell
- microvillus
- coated pit
- actin cytoskeleton
- ruffle
- ruffle membrane
- cytoplasmic vesicle
- cytosol
- clathrin coated vesicle membrane
- clathrin-coated endocytic vesicle
- actin filament
- lysosomal membrane
- plasma membrane
- endocytic vesicle
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- membrane
- unconventional myosin complex
- filopodium
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- minus-end directed microfilament motor activity
- ATP binding
- calmodulin binding
- protein binding
- actin binding
- ADP binding
- microfilament motor activity
- motor activity