Egr2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including nervous system development; protein export from nucleus; and regulation of nervous system development. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including nervous system development; regulation of ossification; and rhythmic behavior. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Egr2 |
| Official Name | early growth response 2 [Source:MGI Symbol;Acc:MGI:95296] |
| Ensembl ID | ENSMUSG00000037868 |
| Bio databases IDs | |
| Aliases | early growth response 2 |
| Synonyms | AC153379.6, AT591, CMT1D, CMT4E, early growth response 2, KROX20, M24377, NGF1-B, Zfp-25, Zfp-6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Egr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- SUMO ligase
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- ubiquitin protein ligase binding
- activation domain
- transcription regulator
- DNA binding domain
- PPXY motif
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Early growth response N-terminal domain
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Egr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- weight loss
- diabetic nephropathy
- experimental autoimmune encephalomyelitis
- Charcot-Marie-Tooth disease axonal type 1d
- Huntington disease
- breast cancer
- autoimmune disease
- osteoporosis
- systemic lupus erythematosus
phenotypes
- abnormal Schwann cell morphology
- abnormal abducens nerve morphology
- abnormal aortic valve morphology
- abnormal bone mineralization
- abnormal bone structure
- abnormal cochlear ganglion morphology
- abnormal cranial ganglia morphology
- abnormal cranial nerve morphology
- abnormal facial nerve morphology
- abnormal gait
- abnormal geniculate ganglion morphology
- abnormal glossopharyngeal ganglion morphology
- abnormal glossopharyngeal nerve morphology
- abnormal hindbrain development
- abnormal long bone epiphyseal plate morphology
- abnormal long bone morphology
- abnormal mandible morphology
- abnormal motor capabilities/coordination/movement
- abnormal motor neuron morphology
- abnormal myelination
- abnormal neural tube morphology
- abnormal neuromuscular synapse morphology
- abnormal neuronal migration
- abnormal rhombomere morphology
- abnormal sciatic nerve morphology
- abnormal skeleton development
- abnormal somatic nervous system morphology
- abnormal spinal cord morphology
- abnormal trigeminal ganglion morphology
- abnormal trigeminal nerve morphology
- abnormal vagus ganglion morphology
- abnormal vagus nerve morphology
- absent rhombomere 3
- absent rhombomere 5
- decreased body size
- decreased body weight
- decreased diameter of femur
- decreased diameter of long bones
- decreased diameter of radius
- decreased diameter of tibia
- decreased length of long bones
- decreased nerve conduction velocity
- decreased rhombomere 3 size
- decreased rhombomere 5 size
- decreased rhombomere 6 size
- decreased width of hypertrophic chondrocyte zone
- delayed eyelid opening
- enlarged aortic valve
- fusion of glossopharyngeal and vagus nerve
- hindlimb paralysis
- hypoactivity
- impaired coordination
- impaired limb coordination
- increased Schwann cell proliferation
- increased pulmonary respiratory rate
- lethality at weaning complete penetrance
- neonatal lethality incomplete penetrance
- paralysis
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- respiratory distress
- short femur
- short radius
- short tibia
- thick aortic valve cusps
- thick pulmonary valve cusps
- tremors
- weakness
- weight loss
role in cell
- production in
- activation in
- binding in
- expression in
- accumulation
- phosphorylation in
- migration
- quantity
- proliferation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Egr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- motor axon guidance
- protein sumoylation
- rhombomere 3 structural organization
- brain segmentation
- positive regulation of Schwann cell differentiation
- facial nerve structural organization
- myelination
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- learning or memory
- response to insulin stimulus
- rhombomere 3 formation
- skeletal muscle cell differentiation
- positive regulation of transcription, DNA-dependent
- regulation of neuronal synaptic plasticity
- Schwann cell differentiation
- rhombomere 5 structural organization
- rhombomere 5 formation
- peripheral nervous system development
- brain development
- protein export from nucleus
- regulation of transcription from RNA polymerase II promoter
- rhythmic behavior
- aorta development
- gene expression
- regulation of ossification
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity