Bach2 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including ganglia; limb bud; reproductive system; telencephalon; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bach2 |
| Official Name | BTB and CNC homology, basic leucine zipper transcription factor 2 [Source:MGI Symbol;Acc:MGI:894679] |
| Ensembl ID | ENSMUSG00000040270 |
| Bio databases IDs | |
| Aliases | BTB and CNC homology, basic leucine zipper transcription factor 2 |
| Synonyms | BTB and CNC homology, basic leucine zipper transcription factor 2, BTBD25, BTB domain and CNC homolog 2, E030004N02Rik, IMD60, LOC653299, RGD1562865 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bach2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- BTB_POZ
- cysteine-proline dipeptide repeat motif
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Broad-Complex, Tramtrack and Bric a brac
- double-stranded DNA binding
- cytoplasmic localization sequence
- BTB/POZ domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ankylosing spondylitis
- rheumatoid arthritis
- COVID-19
- autoimmune disease
- epithelial cancer
- celiac disease
- epithelial basal cell carcinoma
- non-insulin-dependent diabetes mellitus
- tumorigenesis
phenotypes
- abnormal bone structure
- aorta stenosis
- decreased B cell number
- decreased CD11b-high dendritic cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased bone mineral content
- decreased bone mineral density
- decreased cardiac stroke volume
- decreased circulating creatinine level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased fasting circulating glucose level
- decreased follicular B cell number
- decreased food intake
- decreased grip strength
- decreased mature B cell number
- decreased memory-marker NK cell number
- decreased prepulse inhibition
- decreased regulatory T cell number
- decreased respiratory quotient
- decreased vertical activity
- hyperactivity
- increased CD103-positive CD11b-low dendritic cell number
- increased CD11b-low dendritic cell number
- increased CD4-positive alpha-beta memory T cell number
- increased CD8-positive alpha-beta memory T cell number
- increased KLRG1+ CD4 alpha beta T cell number
- increased KLRG1+ CD8 alpha beta T cell number
- increased KLRG1-positive CD4-negative NK T cell number
- increased KLRG1-positive CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased KLRG1-positive NK cell number
- increased KLRG1-positive gamma-delta T cell number
- increased Ly6C high monocyte number
- increased Ly6C low monocyte number
- increased NK cell number
- increased circulating unsaturated transferrin level
- increased effector memory CD8-positive alpha-beta T cell number
- increased effector memory T-helper cell number
- increased eosinophil cell number
- increased grip strength
- increased immature B cell number
- increased macrophage cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker CD4-negative NK T cell number
- increased memory-marker NK cell number
- increased monocyte cell number
- increased neutrophil cell number
- increased pulmonary respiratory rate
- limb grasping
- short tibia
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal circulating creatinine level
- abnormal circulating glucose level
- abnormal class switch recombination
- abnormal fasting circulating glucose level
- abnormal food intake
- abnormal grip strength
- abnormal locomotor activation
- abnormal prepulse inhibition
- abnormal pulmonary respiratory rate
- abnormal respiratory quotient
- abnormal somatic hypermutation frequency
- abnormal tibia morphology
- absent germinal center B cells
- decreased CD4-positive alpha beta T cell number
- decreased IgA level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgG3 level
- decreased marginal zone B cell number
- increased B-1 B cell number
- increased IgM level
- myeloid hyperplasia
- spleen hypoplasia
role in cell
- expression in
- degradation in
- differentiation
- formation
- function
- production in
- killing
- apoptosis
- binding in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bach2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- nuclear import
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity