Trio

Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of fat cell differentiation. Predicted to be located in cell projection and early endosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone. Predicted to be extrinsic component of membrane. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 44 and autosomal dominant intellectual developmental disorder 63 with macrocephaly. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trio often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Trio gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Trio gene, providing context for its role in the cell.