Tlr2 Gene Summary [Rat]
Enables lipopeptide binding activity. Involved in several processes, including positive regulation of defense response; positive regulation of signal transduction; and response to molecule of bacterial origin. Located in cell body; cell projection; and cell surface. Used to study carotid stenosis; ileitis; keratitis; lung disease (multiple); and renal fibrosis. Biomarker of several diseases, including alcohol use disorder; cerebrovascular disease (multiple); familial combined hyperlipidemia; pancreatitis (multiple); and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlr2 |
| Official Name | toll-like receptor 2 [Source:RGD Symbol;Acc:735138] |
| Ensembl ID | ENSRNOG00000009822 |
| Bio databases IDs | |
| Aliases | toll-like receptor 2 |
| Synonyms | CD282, Ly105, TIL4, toll-like receptor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tlr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lipid binding
- signaling receptor activity
- diacylated lipoprotein binding
- SEFIR domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- beta-amyloid binding
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- TIR domain
- identical protein binding
- lipopolysaccharide binding
- triacylated lipoprotein binding
- leucine-rich repeat
- binding protein
- cytoplasmic domain
- BB loop
- transmembrane domain
- intracellular domain
- peptidoglycan binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tlr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- MSP-RON Signaling Pathway
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Osteoarthritis Pathway
- Phagosome Formation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- infection
- tuberculosis
- epithelial cancer
- epithelial neoplasia
- cancer
- motor dysfunction
- chronic lymphocytic leukemia
- mycosis fungoides
- insulin resistance
role in cell
- apoptosis
- binding
- aggregation
- invasion
- phosphorylation in
- expression in
- proliferation
- accumulation in
- growth
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- intracellular compartment
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- Golgi Apparatus
- secretory granule membrane
- cytosol
- apical cell surfaces
- plasma membrane extracellular face
- basolateral membrane
- nucleoplasm
- perinuclear space
- membrane rafts
- cellular protrusions
- perikaryon
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tlr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- I-kappaB phosphorylation
- response to progesterone stimulus
- detection of triacyl bacterial lipopeptide
- detection of diacyl bacterial lipopeptide
- learning
- response to toxin
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of oligodendrocyte differentiation
- inflammatory response
- immune response
- response to hypoxia
- positive regulation of interferon-beta production
- apoptotic process
- central nervous system myelin formation
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- defense response to Gram-positive bacterium
- negative regulation of synapse assembly
- cellular response to triacyl bacterial lipopeptide
- leukotriene metabolic process
- positive regulation of inflammatory response
- positive regulation of interleukin-8 production
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of gene expression
- lipopolysaccharide-mediated signaling pathway
- positive regulation of Wnt receptor signaling pathway
- positive regulation of interleukin-6 production
- cellular response to diacyl bacterial lipopeptide
- negative regulation of phagocytosis
- toll-like receptor 2 signaling pathway
- negative regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- response to insulin stimulus
- positive regulation of interleukin-18 production
- response to fatty acid
- toll-like receptor TLR6:TLR2 signaling pathway
- signal transduction
- nitric oxide metabolic process
- toll-like receptor signaling pathway
- microglial cell activation
- positive regulation of interleukin-12 production
- cellular response to lipoteichoic acid
- innate immune response
- cellular response to bacterial lipopeptide
- cellular response to interferon-gamma
- positive regulation of interleukin-10 production
- microglia development
Cellular Component
Where in the cell the gene product is active
- Toll-like receptor 1-Toll-like receptor 2 protein complex
- Toll-like receptor 2-Toll-like receptor 6 protein complex
- Golgi apparatus
- receptor complex
- cell projection
- plasma membrane
- cell surface
- secretory granule membrane
- cytoplasm
- cell body
- membrane raft
- phagocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- peptidoglycan binding
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- lipopolysaccharide receptor activity
- signaling receptor activity
- triacyl lipopeptide binding
- Toll-like receptor binding
- beta-amyloid binding
- lipopolysaccharide binding