Hspb1 Gene Summary [Rat]
Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of proteasome complex. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspb1 |
| Official Name | heat shock protein family B (small) member 1 [Source:RGD Symbol;Acc:61306] |
| Ensembl ID | ENSRNOG00000023546 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small) member 1 |
| Synonyms | ACTIN POLYMERIZATION INHIBITOR, CMT2F, heat shock protein 1, Heat shock protein 1 beta, Heat shock protein 1 β, heat shock protein family B (small) member 1, HEL-S-102, HMN2B, HMND3, HS.76067, Hsb1, Hsp25, HSP27, HSP28, SRP27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-crystallin domain
- RXXs motif
- protein kinase binding
- protein kinase C binding
- transcription factor binding
- ubiquitin binding
- protein binding
- protein kinase c inhibitor
- identical protein binding
- phosphorylation site
- MAPKAPK2 phosphorylation site
- IxI/V motif
- alpha b-cyrstallin domain
- alpha-crystallin Hsps/p23-like
- protein homodimerization
- Hsp20/alpha crystallin family
Pathways
Biological processes and signaling networks where the Hspb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- epithelial cancer
- endometriosis
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- Charcot-Marie-Tooth disease axonal type 2f
- autosomal dominant distal hereditary motor neuronopathy type 3
- organismal death
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- transmembrane potential
- cell death
- survival
- cell viability
- expression in
- damage in
- formation
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cornified envelope
- cytoskeleton
- cell surface
- intracellular space
- Nucleus
- Plasma Membrane
- centrosome
- myofilaments
- sarcomere
- cytosol
- synaptic membrane
- Golgi membrane
- mitochondrial intermembrane space
- mitochondrial outer membrane
- growth cone
- neurites
- myofibrils
- I band
- Z line
- perikaryon
- axons
- dendrites
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of translational initiation
- protein refolding
- response to virus
- negative regulation of protein kinase activity
- response to unfolded protein
- positive regulation of blood vessel endothelial cell migration
- positive regulation of angiogenesis
- vascular endothelial growth factor receptor signaling pathway
- response to heat
- regulation of protein phosphorylation
- negative regulation of apoptotic process
- regulation of autophagy
- positive regulation of endothelial cell chemotaxis
- positive regulation of tumor necrosis factor production
- cellular response to vascular endothelial growth factor stimulus
- platelet aggregation
- positive regulation of interleukin-1 beta production
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- extracellular space
- cornified envelope
- cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- spindle
- cytosol
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein kinase binding
- identical protein binding
- protein binding involved in protein folding
- protein homodimerization activity
- RNA binding
- protein binding
- ubiquitin binding
- unfolded protein binding
- protein kinase C inhibitor activity