Target List
EGFR Signaling
BCAR1, CBL, EGF, EGFR (ERBB1), EPS8, GAB1, GRB2, HBEGF, NCK2, NUP62, RPS6KA5, SHC1
Platelet-Derived Growth Factor Receptor Signaling
BCAR1, PDGFA, PDGFB, PDGFRA, PLAT (TPA)
Intracellular Signaling
AKT Signaling
AKT1, AKT2, AKT3, BAD, CASP9, CHUK (IKKα), FASLG (TNFSF6), FOXO3, NFKB1, PTEN
ERK1 / ERK2 Signaling
EGFR (ERBB1), ELK1, GRB2, MAP2K1, MAPK1 (ERK2), MAPK3 (ERK1), MKNK1, PDGFRA, RAF1, RPS6KA5, SHC1, SRC, STAT3
IκB Kinase / NFκB Cascade
CHUK (IKKα), FASLG (TNFSF6), GSK3A, GSK3B, NUP62, RHOA, STAT1
JAK / STAT Signaling
EPS8, GAB1, GRB2, JAK1, NUP62, PPP2CA, SRC, STAT1, STAT3, STAT5A
JNK / p38 Signaling
MAP2K4 (MKK4, JNKK1), MAP3K2 (MEKK2), MAPK10 (JNK3), MAPK8 (JNK1), MAPK9 (JNK2)
MAP Kinase Signaling
DUSP1 (PTPN16), DUSP6, EGF, EGFR (ERBB1), MAP2K1, MAP2K7 (JNKK2), MAPK1 (ERK2), MAPK10 (JNK3), MAPK3 (ERK1), MAPK8 (JNK1), MAPK9 (JNK2), PPP2CA, PRKCA, SHC1
PI3 Kinase Signaling
PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PTEN
G-Protein Signaling
GRB2, HRAS, NRAS, NUP62, RAP1A, RASA1, RHOA
Other Intracellular Signaling Molecules
ARAF, BRAF, CBL, CSNK2A1, CSNK2B, IKBKB (IKKβ), NCK2, PDPK1, PLCG1, RPS6KB1
Cell Survival & Growth
Apoptosis
AKT1, BAD, BCAR1, BCL2, BRAF, CASP3, CASP9, FASLG (TNFSF6), FOXO3, IL2, LTA (TNFB), MAPK1 (ERK2), NFKB1, NUP62, PIK3R2 (p85-BETA), PPP2CA, PRKCA, PTEN, RAF1, RASA1, STAT1, TP53 (p53)
Cell Cycle
BCL2, CCND1, DUSP1 (PTPN16), DUSP6, EGFR (ERBB1), HRAS, KRAS, MAPK1 (ERK2), MAPK3 (ERK1), NRAS, PDGFA, PDGFB, PPP2CA, PRKCA, PTEN, RAP1A, SHC1, STAT1, TP53 (p53)
Cell Differentiation
FOXO3, IL2, PPP2CA, TP53 (p53)
Cell Growth
BCAR1, CCND1, EGF, HBEGF, IL2, PDGFA, PDGFB, PDGFRA, PPP2CA, RASA1, SHC1, TP53 (p53)
Cell Motility
ACTR2, BCAR1, EGFR (ERBB1), FN1, HBEGF, MAP2K1, MAPK8 (JNK1), PTEN, STAT3
Cell Proliferation
BCAR1, BCL2, EGF, EGFR (ERBB1), EPS8, GAB1, HBEGF, IL2, NCK2, NUP62, PDGFA, PDGFB, PDGFRA, PTEN, RAF1, SHC1, TP53 (p53)
Metabolism
DNA Metabolism
ATF1, ATF2 (CREB2), CREB1, EGF, EGFR (ERBB1), FOS, NUP62, PPP2CA, TP53 (p53)
Lipid Metabolism
ARAF, BRAF, PIK3R1 (p85-ALPHA), PLCG1, PPP2CA, PRKCA, PTEN, RAF1, SHC1
Protein Metabolism
ACTR2, AKT1, AKT2, AKT3, ARAF, ATF1, ATF2 (CREB2), BRAF, CBL, CHUK (IKKα), CREB1, CSNK2A1, DUSP1 (PTPN16), DUSP6, EGFR (ERBB1), FOS, GSK3A, GSK3B, IKBKB (IKKβ), JAK1, MAP2K1, MAP2K4 (MKK4, JNKK1), MAP2K7 (JNKK2), MAP3K2 (MEKK2), MAPK1 (ERK2), MAPK10 (JNK3), MAPK3 (ERK1), MAPK8 (JNK1), MAPK9 (JNK2), MKNK1, PDGFRA, PDPK1, PPP2CA, PRKCA, PTEN, RAF1, RPS6KA5, RPS6KB1, SRC
Other Metabolism Genes
COL1A1, EIF4E, FN1, MMP7, RASA1
Development
BRAF, COL1A1, HBEGF, PTEN, RASA1, STAT3
Stimulus Response
Response to Wounding
BCAR1, BCL2, FN1, HBEGF, IL2, NCK2, NFKB1, PDGFB, STAT3
Response to Other Stimuli
AKT1, CHUK (IKKα), COL1A1, DUSP1 (PTPN16), EGFR (ERBB1), FASLG (TNFSF6), FOS, KRAS, LTA (TNFB), MAP2K1, MAP2K7 (JNKK2), MAPK1 (ERK2), MAPK8 (JNK1), MAPK9 (JNK2), NFATC3, PPP2CA, RPS6KA5, STAT1, STAT5A, TP53 (p53)
Transcription Factors & Regulators
AKT1, ATF1, ATF2 (CREB2), CBL, CREB1, EGR1, EIF4E, ELK1, FOS, FOXO3, IKBKB (IKKβ), JUN, MKNK1, NFATC3, NFKB1, NUP62, PPP2CA, RPS6KA5, STAT1, STAT3, STAT5A, TP53 (p53)
Actin & Calcium Ion Homeostasis
ACTR2, BCAR1, CBL, EGF, EGFR (ERBB1), MMP7, NCK2, PDPK1, PLCG1, PRKCA, RASA1, RHOA, STAT1, STAT3, STAT5A