Target List
Unfolded Protein Binding
CALR, CANX, CCT4, DNAJB9, DNAJC10, ERO1B (ERO1LB), HSPA1B, HSPA2, HTRA2, PFDN5, PPIA, SCAP, SEC63, SIL1, TCP1, TOR1A, UGGT1
Endoplasmic Reticulum Protein Folding Quality Control
EDEM1, GANAB, GANC, PRKCSH, RPN1, SERP1, ERP44, UGGT1
Regulation of Cholesterol Metabolism
INSIG2, MBTPS1, MBTPS2, SCAP, SREBF1
Regulation of Translation
EIF2A, EIF2AK3, PPP1R15A (GADD34), SERP1
Endoplasmic Reticulum Associated Degradation (ERAD)
AMFR, DERL1, EDEM1, FBXO6, HERPUD1, HTRA2, HTRA4, MBTPS1, MBTPS2, NPLOC4, NUCB1, OS9, SEL1L, SELENOS, SYVN1, SEC62, UBXN4, VCP
Ubiquitination
AMFR, HERPUD1, RNF5, SEL1L, SEC62, UBE2G2, UBXN4, UFD1, USP14, VCP
Transcription Factors
ATF4, ATF6, ATXN3, CALR, CEBPB, CREB3, CREB3L3, ATF6B, DDIT3 (GADD153, CHOP), ERN1, ERN2, MBTPS1, PFDN5, SCAP, SREBF1, XBP1
Protein Folding
CALR, CANX, CCT4, DNAJB9, DNAJC10, ERO1A (ERO1L), HSPA4L (OSP94), PFDN5, PPIA, SEC63, SIL1, TCP1, TOR1A, ERP44, UGGT1
Protein Disulfide Isomerization
DDIT3 (GADD153, CHOP), DNAJC10, ERO1A (ERO1L), ERO1B (ERO1LB), PDIA3, SELENOS, SREBF1, ERP44
Heat Shock Proteins
DNAJB9, DNAJC10, DNAJC3, HSPA4 (HSP70), HSPA5 (GRP78), HSPH1 (HSP105), SEC63
Apoptosis
MANF, ATXN3, BAX, CALR, CEBPB, DDIT3 (GADD153, CHOP), EIF2AK3, ERN1, ERN2, HSPA1B, HTRA2, MAPK8 (JNK1), MAPK9 (JNK2), PDIA3, PPP1R15A (GADD34), SELENOS, VCP
Pathway Activity Signature Genes
ADM2, ASNS, BEX2, DDIT3 (GADD153, CHOP), DNAJB9, GINS2, HERPUD1, INHBE, KCNMB3, MCM4, PCNA, RRM2, SLC17A2, TRIB3 (SKIP3), TYMS, UHRF1