Target List
Differentially Methylated Promoters
APAF1, CADM1 (TSLC1), CDH1 (E-Cadherin), CDH13, CDKN1A (p21CIP1, WAF1), CDKN1B (P27KIP1), CDKN1C (p57Kip2), CDKN2B (p15INK4b), DAPK1, DKK3, DLC1, EGR3, HIC1, JUNB, MEIS1, MLH1, NPM1, PTEN, SFRP2, SFRP4, SFRP5, SOCS1, TP53 (p53), WIF1
BCR-ABL Pathway
ABL1, BCR, GRB2, JAK2, SHC1, STAT3, STAT5A, STAT5B
JAK / STAT Signaling
AKT1, CSF3 (GCSF), IFNA1, IL4, IL6, JAK2, STAT1, STAT3, STAT5A, STAT5B, SOCS1
Hematopoiesis
BCL2, CSF3 (GCSF), CTNNB1, IL4, JAK2, LMO2, PML, RUNX1 (AML1), STAT5A, STAT5B, TAL1, TP53 (p53)
Myeloid Cell Differentiation
CTNNB1, FOXO3, IL4, JUN, LMO2, RUNX1 (AML1), SPI1, STAT5A, STAT5B, TAL1
Immune System Development
BCL2, CSF3 (GCSF), CTNNB1, IL4, JAK2, LMO2, MLH1, PML, RUNX1 (AML1), STAT5A, STAT5B, TAL1, TLX1, TP53 (p53)
Lymphocyte Proliferation & Differentiation
BCL2, CSF3 (GCSF), CTNNB1, IL4, IL6, STAT5A, STAT5B
Cytokines & Chemokines
CCL3 (MIP-1A), CSF3 (GCSF), CXCL10 (INP10), IFNA1, IL1R1, IL4, IL6, CXCL8 (IL8), IL10, IL12A
Malignancy
BAALC, BMPR1B (ALK6), BTG3, CD34, CDC42EP3, CCN2, GAS2L3, MN1, NR4A3 (NOR1), RGS12
Leukemia Therapeutic Targets
AKT1, ALOX5, BCL2, CTNNB1, FGR, FOXO3, HCK, HDAC1, HSP90AA1, IFNA1, JAK2, MCL1, MERTK, MTOR, PML, PRKCB, RAC2, SMO
Leukemia Stem Cell Transcriptional Regulators
CEBPB, GATA1, IKZF3, JUN, LMO1, LMO2, LYL1, MEIS1, NFKB1, RUNX1 (AML1), RUNX2, RUNX3, SPI1, STAT1, STAT3, STAT5A, TAL1, TLX1, TLX3