Target List
Placental Genes Dysregulated During Pre-eclampsia
Early-Onset Pre-eclampsia
ABCG2 (BCRP), ANGPT2, ATP1B1, BCL6, BHLHE40 (DEC1), CFD, COL14A1, CRH, DCN, DUSP1 (PTPN16), F5, FABP4, FLT1 (VEGFR1), FSTL3, HGF, HSD17B1, HTRA1, IGF1, INHA, INHBA, LEP (Leptin), LPL, MMP12, SOD1, SPP1, VCAN
Late-Onset Pre-eclampsia
ABCC1 (MRP1), ABCG2 (BCRP), APLN, ATP2A2, BCL6, BHLHE40 (DEC1), C3, CAV1, CD40LG, CDH13, CLU, CP, CRH, CRHBP, CXCL9 (MIG), CYP26A1, DUSP1 (PTPN16), F5, FLT1 (VEGFR1), FSTL3, HBEGF, HP, HSD17B1, HSP90AA1, HTR3A, HTRA1, IFNG, IGFBP3, IL11, IL15, IL1A, INHA, INHBA, ITGB3, KIT (CD117), KRT19, LEP (Leptin), MAS1, NCAM1, NDRG1, NTRK2, PDGFD, PGR, QPCT, SERPINA3, SOD1, SPP1, STAT1, TAC1, TGFB1, TREM1
Pregnancy
Pregnancy Maintenance
ADM, ANGPT2, CRH, CRHBP, DCN, FLT1 (VEGFR1), HIF1A, HLA-G, IL11, KRT19, LEP (Leptin), PGF, PGR, SOD1, TAC3, TGFB1
Angiogenesis
ANGPT2, C3, CCL2 (MCP-1), CDH13, CXCL10 (INP10), DCN, ENG (EVI-1), FLT1 (VEGFR1), FLT4 (VEGFR2), HIF1A, IL18, IL1A, IL6, CXCL8 (IL8), ITGB3, MMP9, NDRG1, NOS3 (eNOS), PGF, TEK (TIE-2, TIE2), VEGFA
Vasodilation
ADM, AGTR1, APLN, MAS1, NOS3 (eNOS)
Tissue Remodeling
MMP9, MMP12, PAPPA2, SERPINA3
Inflammation
AGTR1, BCL6, C3, CCL2 (MCP-1), CD40LG, CRH, CXCL10 (INP10), CXCL9 (MIG), FABP4, IL10, IL15, IL18, IL1A, IL2, IL6, CXCL8 (IL8), SERPINA3, SPP1, TAC1, TGFB1, TNF
Oxidative Stress
CLU, CYP26A1, DUSP1 (PTPN16), HIF1A, MMP9, SOD1
Cell Adhesion Molecules
CAV1, CD40LG, CDH13, COL14A1, ENG (EVI-1), FSTL3, ITGB3, NCAM1, SPP1, VCAN
Cells Involved in Pre-eclampsia
Th1 Cells
CD40LG, IFNG, IL18, IL2, STAT1, TNF, VEGFA
Endothelial Cells
ANGPT2, CAV1, CCL2 (MCP-1), CD40LG, CDH13, EDN1, FLT4 (VEGFR2), HIF1A, ITGB3, NOS3 (eNOS), TEK (TIE-2, TIE2), TGFB1, VEGFA
Neutrophils
CCL2 (MCP-1), EDN1, IFNG, IL6, CXCL8 (IL8), TREM1
Natural Killer Cells
IL2, IL15, IL18
Hemostasis & Heme Metabolism
ABCG2 (BCRP), ATP1B1, ATP2A2, C3, CFD, CYP26A1, F5, HP, INHA, INHBA
Hormones & Growth Factors
ADM, APLN, CRH, CRHBP, EDN1, HBEGF, HGF, IGF1, INHA, INHBA, LEP (Leptin), PDGFD, PGF, QPCT, TAC1, TAC3
Signal Transduction
Nitric Oxide Signaling
CAV1, EDN1, ENG (EVI-1), HSP90AA1, NOS3 (eNOS)
Insulin Signaling
HTRA1, IGF1, IGFBP3