Target List
TGFβ Superfamily Ligands
Activins
Inha, Inhba
Bone Morphogenetic Proteins
Amh, Bmp1, Bmp2, Bmp3, Bmp4, Bmp5, Bmp6, Bmp7, Gdf1, Gdf2 (Bmp9), Gdf3 (Vgr-2), Gdf5 (Cdmp-1), Gdf6, Gdf7
Nodal
Nodal
TGFβ Family Members
Tgfb1, Tgfb2, Tgfb3
Inhibitor & Cofactors of TGFβ Signaling
Bambi, Chrd, Dcn, Fst, Lefty1, Ltbp1, Ltbp2, Ltbp4, Nog, Tdgf1, Tgfbi, Tgfbrap1, Thbs1 (TSP-1)
TGFβ Superfamily Receptors
Activin Receptors
Acvr1 (Alk2), Acvr2a, Acvrl1 (Alk1)
Bone Morphogenetic Protein Receptors
Amhr2, Bmpr1a (Alk3), Bmpr1b (Alk6), Bmpr2
TGFβ Receptors
Tgfbr1 (ALK5), Tgfbr2, Tgfbr3
Transcription Factors & Regulators
Dlx2, Fos, Gsc, Id1, Jun, Junb, Myc, Runx1 (Aml1), Smad1, Smad2, Smad3, Smad4, Smad5, Smad7, Sox4, Stat1, Tgfb1i1, Tsc22d1
SMAD Target Genes
TGFβ / Activin-Responsive
Atf4, Cdkn1a (p21Cip1, Waf1), Cdkn1b (p27Kip1), Cdkn2b (p15INK4b), Col1a1, Col1a2, Dcn, Emp1, Fos, Gadd45b, Gsc, Herpud1, Ifrd1, Igf1, Igfbp3, Il6, Jun, Junb, Myc, Pdgfb, Serpine1 (Pai-1), Tgfb1i1, Tnfsf10 (Trail), Tsc22d1, Tgfbi
Bone Morphogenetic Protein Responsive
Bglap2, Dlx2, Id1, Id2, Junb, Sox4, Stat1
Molecules Regulating TGFβ Superfamily Signaling
Bambi, Bmper, Cdkn2b (p15INK4b), Chrd, Eng (Evi-1), Mecom, Fst, Nog, Plau (uPA), Runx1 (Aml1), Smurf1
Extracellular Matrix (ECM) & Cell Adhesion Molecules
Cell Adhesion Molecules
Bglap2, Eng (Evi-1), Tgfb1i1, Tgfbi
Extracellular Matrix (ECM) Structural Constituents
Bglap2, Col1a1, Col1a2, Ltbp1, Ltbp2, Tgfbi
Cellular & Developmental Processes
Apoptosis
Cdkn1a (p21Cip1, Waf1), Cdkn1b (p27Kip1), Igfbp3, Inha, Inhba, Stat1, Tgfb1
Embryonic Development
Bmp4, Inhba, Mecom, Smad3, Smurf1, Tdgf1
Muscle Development
Dcn, Igf1, Smad3
Neurogenesis
Dlx2, Inha, Inhba, Nog
Reproduction
Amh, Amhr2, Fst, Inha, Inhba
Skeletal Development
Bglap2, Bmp1, Bmp2, Bmp3, Bmp4, Bmp5, Bmp6, Bmp7, Bmpr2, Chrd, Col1a1, Col1a2, Igf1, Inha, Inhba, Nog