Target List
Up-Regulated in Nephrotoxicity
Apoptosis
Angptl4, Anxa5, Btg2, Cd24a, Cd44, Cdkn1a (p21Cip1, Waf1), Clu, Gadd45a, Gstp1, Hmox1, Nqo1, Rtn4, Socs3, Tnfrsf12a
Cell Cycle
Ccnd1, Ccng1, Cdkn1a (p21Cip1, Waf1), Gadd45a, Mcm6
Metal Ion Binding
Bmp1, Ccs, Cp, Ctss, Hmox1, Hmox2, Mt1
Oxidative Stress
Clu, G6pdx, Gpx8, Hmox1, Hmox2, Nqo1
Cell Proliferation
Atf3, Btg2, Ccnd1, Cd24a, Cdkn1a (p21Cip1, Waf1), Clu, Cxcl10 (Inp10), Cxcl3, Glul, Gpnmb, Hmox1, Hsp90aa1, Timp1, Uchl1, Vcam1
Tissue Remodeling
Cst3, Fn1, Havcr1 (Kim-1), Spp1, Timp1
Transporters
Abcb1a (Mdr1), Abcc2 (Mrp2, cMOAT)
Xenobiotic Metabolism
Cyp2c54, Gstp1, Ugt1a6a
Extracellular Matrix (ECM) Molecules
Angptl4, Ccl3 (Mip-1a), Cd44, Cst3, Fgb, Lgals3, Mgp, Timp1
Cytoskeleton Regulators
Ccl3 (Mip-1a), G6pdx, Sprr1a, Tmsb10, Vim
Other Genes Up-Regulated in Nephrotoxicity
A2m, Gc, Igfbp1, Lcn2 (Ngal), Ugt1a1
Down-Regulated in Nephrotoxicity
Apoptosis
Bmp4, Cat, Ghr, Igfbp3, Sod2
Cell Cycle
Bmp4, Egf
Metal Ion Binding
Bhmt, Idh1, Rgn, Scd1, Sod2, Sod3
Oxidative Stress
Cat, Gatm, Idh1, Sod2, Sod3
Cell Proliferation
Bmp4, Egf, Igfbp3, Nox4, Odc1, Sod2
Transporters
Slc22a1, Slc22a5, Slc22a6
Xenobiotic Metabolism
Cyp2d22, Fmo2, Gstk1
Extracellular Matrix (ECM) Molecules
Bmp4, Ccn1, Sod3
Other Genes Down-Regulated in Nephrotoxicity
Aass, Aldh1a1 (Raldh1), Calb1, G6pc, Gamt, Ipmk, Klk1, Nphs2, Oat