Target List
Oncogenes & Tumor Suppressor Genes
AMFR, ANAPC10, ANAPC11, ANAPC13, ANAPC4, ANAPC5, ANAPC7, APC2, BARD1, BIRC3, BIRC7, BRCA1, BTRC, CBL, CBLB, CBLC, CBLL1, CDC16, CDC20, CDC23, CDC27, CDH1 (E-cadherin), CUL7, FBXO5, FBXW5, FBXW7, LOC100622859, MDM2, MDM4, RCHY1, RFWD2, RNF139, SIAH1, SIAH2, SKP2, TRAF2, TRAF5, TRAF6, TRAF7, VHL, XIAP
HECT
HACE1, HECTD1, HECTD2, HECTD3, HECW1, HERC1, HERC2, HERC3, HERC4, HERC5, HERC6, HUWE1, ITCH, NEDD4, NEDD4L, SMURF1, SMURF2, TRIP12, UBE3A, UBE3B, UBE3C, UBR5, WWP1
U-Box
NOSIP, STUB1, UBE4A, UBE4B, WDSUB1
UBL
PIAS1, PIAS2, PIAS4, RANBP2, RBX1, TOPORS, UHRF2
Single RING-Finger
BIRC/IAP
BIRC3, BIRC7, LOC100622859, XIAP
BRE1
RNF20, RNF40
CBL
CBL, CBLB, CBLC, CBLL1
Deltex
DTX3, DTX4, RNF146
Goliath
RNF13, RNF128, RNF130, RNF167
Makorin
MKRN1, MKRN2
Membrane-Associated Ring Finger Proteins
MARCH1, MARCH11, MARCH2, MARCH3, MARCH5, MARCH6, MARCH7, MARCH8
MDM
MDM2, MDM4
Mindbomb Homologs
MIB1, MIB2
NFX
NFX1, NFXL1
PDZRN
LNX1, PDZRN3, PDZRN4
Pellino
PELI1, PELI2
PEX
PEX2, PEX12
Polycomb Group Genes
BMI1 (PCGF4), CBX8, PCGF2, PCGF3, PCGF5, RING1
Praja
PJA1, PJA2, RNF115, RNF126
RBR
ANKIB1, ARIH1, ARIH2, PARK2, RBCK1, RNF14, RNF144A, RNF144B, RNF19A, RNF19B, RNF216, RNF31
RC3H
RC3H1, RC3H2
RKHD
MEX3A, MEX3C, MEX3D
Seven in Absentia
SIAH1, SIAH2
TRAC-I
RNF114, RNF125, RNF138, RNF166
TRAF
TRAF2, TRAF3, TRAF4, TRAF5, TRAF6, TRAF7
TRIM / RBCC
LOC100513415, LOC100524034, LOC733579, MID1, MID2, MURF3, PML, RNF135, TRIM10, TRIM11, TRIM13, TRIM17, TRIM2, TRIM21, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM3, TRIM31, TRIM32, TRIM33, TRIM36, TRIM37, TRIM38, TRIM39, TRIM4, TRIM40, TRIM41, TRIM44, TRIM45, TRIM52, TRIM55, TRIM56, TRIM62, TRIM63, TRIM67, TRIM68, TRIM71, TRIM72, TRIM8, TRIM9, TRIML1
UBR Box
UBR1, UBR2, UBR3, UBR4, UBR7
VPS
VPS11, VPS18, VPS41, VPS8
ZNRF
ZNRF1, ZNRF2
Other Single RING-Finger Proteins
AMFR, ATRX, BCOR, BFAR, BRAP, BRCA1, CCNB1IP1, CDC34, CGRRF1, CHFR, CNOT4, DCST1, DZIP3, FANCL, HLTF, IRAK1, IRF2BPL, LOC102167889, LONRF1, LRSAM1, LTN1, MALT1, MNAT1, MAP3K1 (MEKK1), MEX3D, MGRN1, MSL2, MUL1, MYCBP2, MYLIP, NEURL1, NHLRC1, OSTM1, PAX6, PHRF1, RAD18, RBBP6, RCHY1, RFWD2, RNF10, RNF103, RNF11, RNF111, RNF113A, RNF121, RNF123, RNF139, RNF145, RNF150, RNF152, RNF168, RNF170, RNF180, RNF181, RNF187, RNF207, RNF208, RNF212, RNF215, RNF219, RNF220, RNF24, RNF26, RNF34, RNF38, RNF4, RNF41, RNF43, RNF44, RNF5, RNF6, RNF8, RSPRY1, SHPRH, SYVN1, TNFAIP3, TOPORS, TRAIP, TTC3, UBC, UNK, UNKL, WHSC1, ZER1
Multi-Subunit RING-Finger
SCF Complex
BTRC, CCNF, CUL1, FBXL12, FBXL14, FBXL15, FBXL17, FBXL18, FBXL2, FBXL20, FBXL3, FBXL4, FBXL5, FBXO11, FBXO17, FBXO18, FBXO2, FBXO21, FBXO22, FBXO25, FBXO3, FBXO30, FBXO31, FBXO32, FBXO33, FBXO4, FBXO43, FBXO44, FBXO5, FBXO6, FBXO7, FBXO9, FBXW11, FBXW2, FBXW4, FBXW5, FBXW7, FBXW8, LMO7, RBX1, SKP1, SKP2, TSPAN17
ECV Complex
CUL2, FEM1B, RBX1, TCEB1, TCEB2, VHL, ZYG11B
CUL3 Complex
BTBD1, BTBD2, CUL3, DIABLO, ENC1, GAN, KLHL41, KBTBD7, KCTD10, KEAP1, KLHL13, KLHL2, KLHL20, KLHL21, KLHL22, KLHL24, KLHL7, KLHL9, RBX1, RHOBTB1, RHOBTB3, SPOP, TNFAIP1, ZBTB16
CUL4 Complex
CRBN, CUL4A, CUL4B, DDA1, DDB1, DDB2, DET1, DTL, PHIP, RBX1, RFWD2, VPRBP
ECS Complex
ASB1, ASB18, ASB2 (ASB2), ASB3, ASB9, CISH, CUL5, LRRC41, RNF7, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SPSB1, SPSB2, SPSB4, TCEB1, TCEB2, WSB1
CUL7 Complex
CUL7, RBX1, SKP1
APC/C
ANAPC10, ANAPC11, ANAPC13, ANAPC2, ANAPC4, ANAPC5, ANAPC7, APC2, CDC16, CDC20, CDC23, CDC27, CDH1 (E-cadherin)
BRCC Complex
BARD1, BRCA1, BRCA2, BRCC3, RAD51
KPC Complex
RNF123
Multi-Subunit RING-Finger Cullins & Adaptors
ANAPC11, APC2, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, DDB1, RBX1, RNF7, SKP1, TCEB1, TCEB2