MYO18B Gene Summary
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MYO18B |
| Official Name | myosin XVIIIB [Source:HGNC Symbol;Acc:HGNC:18150] |
| Ensembl ID | ENSG00000133454 |
| Bio databases IDs | |
| Aliases | myosin XVIIIB |
| Synonyms | 1700095B10RIK,4932408L24Rik,4933411E19,4933411E19Rik,Gm448,KFS4,LOC103690078,myosin XVIIIB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- TATA element modulatory factor 1 TATA binding
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- Family with sequence similarity 184, A and B
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- exonuclease SbcC
- Ezrin/radixin/moesin, alpha-helical domain
- Myosin and Kinesin motor domain
- Double-strand recombination repair protein
- Hyaluronan mediated motility receptor N-terminal
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- Domain of unknown function (DUF4686)
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- Trichohyalin-plectin-homology domain
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
- Domain of unknown function (DUF4472)
Pathways
Biological processes and signaling networks where the MYO18B gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- autosomal recessive Klippel-Feil syndrome with nemaline myopathy and facial dysmorphism type 4
- COVID-19
- acute myeloid leukemia
- bipolar disorder
- major depression
- Brugada syndrome
- nemaline myopathy
- uterine leiomyoma
- leiomyomatosis
role in cell
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- actin filaments
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYO18B gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- in utero embryonic development
- actomyosin structure organization
- cardiac muscle cell development
- vasculogenesis
cellular COMPONENT
Where in the cell the gene product is active
- Z disc
- nucleus
- cytoplasm
- myosin II complex
- unconventional myosin complex
- myosin filament
- filamentous actin
molecular FUNCTION
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- motor activity