SOCS3 Gene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SOCS3 |
| Official Name | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] |
| Ensembl ID | ENSG00000184557 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 3 |
| Synonyms | ATOD4,CIS3,CISH3,EF-10,Soc3,Sosc3,SSI-3,Suppressor of cytokine signaling 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pre-SH2 domain
- kinase inhibitory region domain
- protein kinase inhibitor activity
- linker domain
- phosphotyrosine binding
- protein binding
- proline rich domain
- phosphorylation site
- RNA binding
- SOCS box
- extended SH2-subdomain
- elongin B/C binding domain
- SOCS domain
- protein tyrosine kinase inhibitor activity
- phosphatase
- Src homology 2 (SH2) domain
- SOCS
Pathways
Biological processes and signaling networks where the SOCS3 gene plays a role, providing insight into its function and relevance in health or disease.
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-22 Signaling
- IL-6 Signaling
- IL-9 Signaling
- Insulin Receptor Signaling
- JAK/Stat Signaling
- Leptin Signaling in Obesity
- Prolactin Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- STAT3 Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- Type I Diabetes Mellitus Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metastasis
- ulcerative colitis
- asthma
- tumorigenesis
- airway hyperresponsiveness
- atherosclerosis
role in cell
- adhesion
- proliferation
- phosphorylation in
- binding in
- formation
- formation in
- apoptosis
- expression in
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SOCS3 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- placenta blood vessel development
- negative regulation of inflammatory response
- branching involved in labyrinthine layer morphogenesis
- phosphatidylinositol phosphorylation
- positive regulation of cell differentiation
- negative regulation of tyrosine phosphorylation of STAT protein
- negative regulation of insulin receptor signaling pathway
- negative regulation of JAK-STAT cascade
- negative regulation of apoptotic process
- T-helper 17 cell lineage commitment
- intracellular signal transduction
- protein ubiquitination
cellular COMPONENT
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytosol
- internal side of plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- phosphotyrosine binding
- miRNA binding
- protein binding
- protein tyrosine kinase inhibitor activity
- protein kinase inhibitor activity
- 1-phosphatidylinositol-3-kinase regulator activity