CD3E [Human] | GeneGlobe

CD3E Gene Summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Details

Type	Retained Intron
Official Symbol	CD3E
Official Name	CD3e molecule [Source:HGNC Symbol;Acc:HGNC:1674]
Ensembl ID	ENSG00000198851
Bio databases IDs	NCBI: 916 Ensembl: ENSG00000198851
Aliases	CD3e molecule, CD3 epsilon subunit of T-cell receptor complex, T-cell surface glycoprotein CD3 epsilon chain
Synonyms	CD3,CD3A,CD3 antigen, epsilon polypeptide,CD3 antigen, ε polypeptide,CD3epsilon,CD3 (epsilon chain),CD3 epsilon subunit of T-cell receptor complex,Cd3-ε,CD3 (ε chain),CD3 ε subunit of T-cell receptor complex,IMD18,T3E,TCR,TCRE,Tcr-epsilon,Tcr-ε
Species	Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

nucleolin binding domain
Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
immunoglobulin domain
protein binding
proline rich domain
identical protein binding
SH3-domain binding
T-cell surface glycoprotein CD3 delta chain
phosphorylation site
arginine-lysine rich domain
ER retention sequence
itam like domain
cytoplasmic domain
stalk region
CXXC motif
Immunoreceptor tyrosine-based activation motif
intracellular domain
cytosolic tail domain
transmembrane receptor

Pathways

Biological processes and signaling networks where the CD3E gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

binds

disease

acute myeloid leukemia
T-cell/histiocyte rich large B-cell lymphoma
precursor B-cell acute lymphoblastic leukemia
epithelial cancer
myasthenia gravis
immunodeficiency 18 severe combined immunodeficiency variant
B-cell acute lymphoblastic lymphoma
cancer
acute lymphoblastic lymphoma
immunodeficiency 18

regulated by

cytochrome C
TNF
NCK1
TP53
Immunoglobulin
dexamethasone
2B4 cells
lipopolysaccharide
TCR (complex)
BTN2A2

regulates

role in cell

activation in
proliferation
expression in
growth
differentiation
phosphorylation in
apoptosis
cell viability
binding
survival

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Plasma Membrane
detergent-insoluble membrane fraction
soluble fraction
membrane fraction
Cytoplasm
cell surface
intracellular space
cellular membrane
Nucleus
Golgi Apparatus
Endoplasmic Reticulum
intercellular junctions
immunological synapses
microsome
plasma membrane extracellular face
nuclear envelope
dendritic spines
membrane rafts
perikaryon
detergent-soluble fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CD3E gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in

signal complex assembly
T cell activation
apoptotic signaling pathway
alpha-beta T cell activation
positive regulation of calcium-mediated signaling
CD4-positive, alpha-beta T cell proliferation
positive regulation of interferon-gamma production
calcium-mediated signaling
positive regulation of cell-cell adhesion mediated by integrin
positive regulation of peptidyl-tyrosine phosphorylation
T cell receptor signaling pathway
dendrite development
positive regulation of interleukin-2 production
gamma-delta T cell activation
T cell costimulation
G-protein coupled receptor signaling pathway
macromolecular complex assembly
cerebellum development
adaptive immune response
transmembrane receptor protein tyrosine kinase signaling pathway
smoothened signaling pathway
regulation of apoptotic process
cell surface receptor signaling pathway
positive thymic T cell selection
positive regulation of T cell proliferation
negative regulation of smoothened signaling pathway
T cell anergy
negative regulation of gene expression
positive regulation of T cell anergy
positive regulation of cell-matrix adhesion
positive regulation of gene expression
negative thymic T cell selection
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of interleukin-4 production

cellular COMPONENT

Where in the cell the gene product is active

cell-cell junction
dendritic spine
cell body
external side of plasma membrane
T cell receptor complex
endoplasmic reticulum
Golgi apparatus
plasma membrane
alpha-beta T cell receptor complex
immunological synapse
gamma-delta T cell receptor complex

molecular FUNCTION

What the gene product does at the molecular level

protein kinase binding
identical protein binding
transmembrane signaling receptor activity
protein binding
T cell receptor binding
SH3 domain binding
receptor signaling complex scaffold activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.

dPCR

qPCR