Agtr1a Gene Summary [Mouse]
Enables angiotensin type I receptor activity. Involved in gene expression; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; regulation of blood pressure; and regulation of smooth muscle cell apoptotic process. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; artery disease (multiple); chronic kidney disease; neurodegenerative disease (multiple); and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Agtr1a |
| Official Name | angiotensin II receptor, type 1a [Source:MGI Symbol;Acc:MGI:87964] |
| Ensembl ID | ENSMUSG00000049115 |
| Bio databases IDs | |
| Aliases | angiotensin II receptor, type 1a |
| Synonyms | 1810074K20Rik, AG2S, Agt1ar, Agtr1, AI551199, angiotensin II receptor, type 1a, Angtr-1a, AT1, AT1A, At1ar, AT1R, At1 receptor, AT2R1, AT2R1A, ATR1, ATR1a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agtr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- protein kinase binding
- DRY motif
- G-protein-coupled receptor binding
- angiotensin type I receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- angiotensin type II receptor
- cytoplasmic domain
- YIPP motif
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Agtr1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- fibrosis
- hyperplasia
- obesity
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- hypertension
- acute lung injury
- bradycardia
- hydronephrosis
- perivascular fibrosis
phenotypes
- abnormal erythrocyte cell number
- abnormal hematocrit
- abnormal hemoglobin content
- abnormal kidney morphology
- decreased body weight
- increased spleen weight
- abnormal amygdala morphology
- abnormal blood homeostasis
- abnormal cardiovascular system physiology
- abnormal heart left ventricle morphology
- abnormal heart rate
- abnormal juxtaglomerular apparatus morphology
- abnormal kidney blood vessel morphology
- abnormal kidney interlobular artery morphology
- abnormal kidney interstitium morphology
- abnormal kidney physiology
- abnormal physiological response to xenobiotic
- abnormal response/metabolism to endogenous compounds
- abnormal systemic arterial blood pressure
- abnormal thalamus morphology
- cardiac fibrosis
- cardiac interstitial fibrosis
- decreased circulating angiotensinogen level
- decreased circulating renin level
- decreased heart rate
- decreased heart weight
- decreased mean systemic arterial blood pressure
- decreased physiological sensitivity to xenobiotic
- decreased susceptibility to injury
- decreased systemic arterial blood pressure
- decreased systemic arterial systolic blood pressure
- decreased urine creatinine level
- decreased urine potassium level
- high mean erythrocyte cell number
- hypotension
- increased blood urea nitrogen level
- increased circulating renin level
- increased fluid intake
- increased heart weight
- increased hemoglobin content
- increased renin activity
- increased systemic arterial blood pressure
- increased systemic arterial systolic blood pressure
- increased urine osmolality
- juxtaglomerular cell hyperplasia
- oliguria
- renal fibrosis
role in cell
- expression in
- proliferation
- production in
- apoptosis
- phosphorylation in
- activation in
- growth
- quantity
- cellular infiltration by
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- endosomes
- vesicles
- Golgi Apparatus
- granules
- plasma membrane projections
- basolateral membrane
- recycling endosomes
- cytoplasmic vesicles
- dendrites