Agtr2 Gene Summary [Mouse]
Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; metanephros development; and regulation of systemic arterial blood pressure by renin-angiotensin. Acts upstream of or within brain renin-angiotensin system and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agtr2 |
| Official Name | angiotensin II receptor, type 2 [Source:MGI Symbol;Acc:MGI:87966] |
| Ensembl ID | ENSMUSG00000068122 |
| Bio databases IDs | |
| Aliases | angiotensin II receptor, type 2 |
| Synonyms | angiotensin II receptor type 2, angiotensin II receptor, type 2, Angiotensin receptor 2, AT2, AT2-R, AT2 receptor, ATGR2, AT<sub>2</sub>R, MRX88 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agtr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- angiotensin type II receptor
- cytoplasmic domain
- receptor antagonist activity
- cytoplasmic loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Agtr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- cystic fibrosis
- hypertension
- neoplasia
- cardiac hypertrophy
- dilation of ureter
- aortic valve stenosis
- heart failure with preserved ejection fraction
- cardiotoxicity
- COVID-19
phenotypes
- abnormal aldosterone level
- abnormal amygdala morphology
- abnormal baroreceptor physiology
- abnormal bone trabecula morphology
- abnormal circulating insulin level
- abnormal circulating leptin level
- abnormal corticosterone level
- abnormal eating behavior
- abnormal epididymal fat pad morphology
- abnormal fluid intake
- abnormal glucose homeostasis
- abnormal habenula morphology
- abnormal heart left ventricle morphology
- abnormal heart rate
- abnormal hippocampus CA1 region morphology
- abnormal hippocampus CA2 region morphology
- abnormal hippocampus CA3 region morphology
- abnormal kidney cortex morphology
- abnormal kidney development
- abnormal kidney morphology
- abnormal lipid homeostasis
- abnormal myocardial fiber morphology
- abnormal pancreas morphology
- abnormal piriform cortex morphology
- abnormal renal/urinary system morphology
- abnormal renal/urinary system physiology
- abnormal respiratory quotient
- abnormal response/metabolism to endogenous compounds
- abnormal systemic arterial blood pressure
- abnormal thalamus morphology
- abnormal triglyceride level
- abnormal ureter development
- abnormal ureter morphology
- abnormal urine homeostasis
- abnormal urine sodium level
- abnormal vascular smooth muscle morphology
- abnormal vasculogenesis
- abnormal vasoconstriction
- absent kidney
- altered response to myocardial infarction
- cardiac fibrosis
- decreased angiogenesis
- decreased body temperature
- decreased body weight
- decreased circulating LDL cholesterol level
- decreased circulating alanine transaminase level
- decreased exploration in new environment
- decreased heart left ventricle weight
- decreased heart weight
- decreased incidence of tumors by chemical induction
- decreased kidney apoptosis
- decreased kidney weight
- decreased pancreas weight
- decreased renal plasma flow rate
- decreased response of heart to induced stress
- decreased startle reflex
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to weight gain
- decreased white fat cell size
- dilated heart left ventricle
- dilated ureter
- double ureter
- ectopic kidney
- hydronephrosis
- hydroureter
- hypoactivity
- hypoalgesia
- increased adrenaline level
- increased angiogenesis
- increased bone trabecula number
- increased bone volume
- increased circulating adrenocorticotropin level
- increased circulating corticosterone level
- increased energy expenditure
- increased fear-related response
- increased fluid intake
- increased insulin sensitivity
- increased mean systemic arterial blood pressure
- increased noradrenaline level
- increased physiological sensitivity to xenobiotic
- increased renal vascular resistance
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to injury
- increased systemic arterial blood pressure
- increased systemic arterial diastolic blood pressure
- increased systemic arterial systolic blood pressure
- increased trabecular bone connectivity density
- increased trabecular bone thickness
- increased vasoconstriction
- increased white fat cell number
- large ureter
- pancreas fibrosis
- pancreatic acinar cell atrophy
- polycystic kidney
- renal hypoplasia
- renal interstitial fibrosis
- thin interventricular septum
- thin ventricular wall
- ureteropelvic junction atresia
- ureteropelvic junction stenosis
- ureterovesical junction obstruction
- vascular smooth muscle hypertrophy
- vesicoureteral reflux
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- phosphorylation in
- quantity
- size
- growth
- migration
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial inner membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agtr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
- vasodilation
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin
- inflammatory response
- negative regulation of nerve growth factor receptor signaling pathway
- negative regulation of cell growth
- positive regulation of metanephric glomerulus development
- positive regulation of transcription, DNA-dependent
- negative regulation of heart rate
- neuron apoptotic process
- negative regulation of blood vessel endothelial cell migration
- G-protein coupled receptor signaling pathway
- angiotensin-mediated signaling pathway
- cell surface receptor signaling pathway
- brain development
- vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
- regulation of blood pressure
- brain renin-angiotensin system
- nitric oxide-cGMP-mediated signaling pathway
- positive regulation of branching involved in ureteric bud morphogenesis
- blood vessel remodeling
- positive regulation of phosphoprotein phosphatase activity
- positive regulation of extrinsic apoptotic signaling pathway
- regulation of metanephros size
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- angiotensin type II receptor activity
- receptor antagonist activity