Nostrin Gene Summary [Rat]
Predicted to enable DNA binding activity. Predicted to be involved in endocytosis and signal transduction. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nostrin |
| Official Name | nitric oxide synthase trafficking [Source:RGD Symbol;Acc:727920] |
| Ensembl ID | ENSRNOG00000006611 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase trafficking |
| Synonyms | DaIP2, LOC311111, LOC329416, mDaIP2, nitric oxide synthase trafficker, nitric oxide synthase trafficking |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nostrin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Fes/CIP4, and EFC/F-BAR homology domain
- coiled-coil domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- Hr1 repeat
- DNA binding
- HR1
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Nostrin gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- alcoholic cirrhosis
- choroidal neovascularization
role in cell
- proliferation
- expression in
- phosphorylation in
- migration
- adhesion
- invasion by
- tubulation by
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endocytic vesicle membrane
- cytoskeleton
- perinuclear region
- filamentous network
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- actin filaments
- granules
- cytosol
- perinuclear space
- peripheral vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nostrin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- signal transduction
- actin filament organization
- endocytosis
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding