Smo Gene Summary [Rat]
Predicted to enable several functions, including cAMP-dependent protein kinase inhibitor activity; oxysterol binding activity; and patched binding activity. Involved in several processes, including negative regulation of hepatocyte proliferation; neuron projection development; and positive regulation of hepatic stellate cell activation. Located in axonal growth cone; dendritic growth cone; and neuronal cell body. Is active in postsynapse. Used to study Barrett's esophagus; esophagus adenocarcinoma; liver cirrhosis; and middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smo |
| Official Name | smoothened, frizzled class receptor [Source:RGD Symbol;Acc:3726] |
| Ensembl ID | ENSRNOG00000008332 |
| Bio databases IDs | |
| Aliases | smoothened, frizzled class receptor |
| Synonyms | bnb, CRJS, E130215L21Rik, FZD11, Gx, PHLS, SMOH, Smoothened, smoothened, frizzled class receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- oxysterol binding
- Frizzled/Smoothened family membrane region
- protein kinase A binding
- protein kinase binding
- cAMP-dependent protein kinase inhibitor activity
- Fz domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
- patched binding
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Smo gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Aldosterone Signaling in Epithelial Cells
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Corticotropin Releasing Hormone Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Protein Kinase A Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Sonic Hedgehog Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- cancer
- epithelial cancer
- adenoma formation
- hyperplasia
- basal cell nevus syndrome
- hypothalamic hamartomas
- secondary acute myeloid leukemia
- hepatocellular carcinoma
role in cell
- expression in
- cell viability
- proliferation
- migration
- formation in
- quantity
- production in
- activation in
- differentiation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- endocytic vesicle membrane
- axon component
- intracellular membrane-bounded organelle
- ciliary tip
- non-motile cilium
- Cytoplasm
- cilia
- cell surface
- postsynaptic region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- centriole
- cytoplasmic aggregates
- ER-to-Golgi intermediate compartment
- caveolae
- late endosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- contact inhibition
- epithelial-mesenchymal cell signaling
- midgut development
- somite development
- ventral midline determination
- anterior/posterior pattern specification
- spinal cord dorsal/ventral patterning
- central nervous system neuron differentiation
- thalamus development
- mammary gland epithelial cell differentiation
- neuroblast proliferation
- negative regulation of DNA binding
- epithelial cell proliferation
- in utero embryonic development
- apoptotic process
- heart looping
- cell fate specification
- positive regulation of epithelial cell proliferation
- dorsal/ventral neural tube patterning
- positive regulation of protein import into nucleus
- G-protein coupled receptor signaling pathway
- determination of left/right asymmetry in lateral mesoderm
- positive regulation of organ growth
- pattern specification process
- positive regulation of neuroblast proliferation
- smoothened signaling pathway
- positive regulation of mesenchymal cell proliferation
- cerebral cortex development
- dentate gyrus development
- positive regulation of branching involved in ureteric bud morphogenesis
- negative regulation of gene expression
- negative regulation of epithelial cell differentiation
- central nervous system development
- neural crest cell migration
- myoblast migration
- protein import into nucleus
- positive regulation of gene expression
- gene expression
- hair follicle morphogenesis
- positive regulation of cell migration
- multicellular organism growth
- pancreas morphogenesis
- odontogenesis of dentin-containing tooth
- vasculogenesis
- forebrain morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- cerebellar cortex morphogenesis
- positive regulation of multicellular organism growth
- negative regulation of transcription from RNA polymerase II promoter
- astrocyte activation
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation
- skeletal muscle fiber development
- cellular response to cholesterol
- osteoblast differentiation
- left/right axis specification
- commissural neuron axon guidance
- smooth muscle tissue development
- atrial septum morphogenesis
- type B pancreatic cell development
- regulation of heart morphogenesis
- homeostasis of number of cells within a tissue
- dopaminergic neuron differentiation
- negative regulation of apoptotic process
- negative regulation of protein phosphorylation
- positive regulation of smoothened signaling pathway
- protein stabilization
- negative regulation of hair follicle development
Cellular Component
Where in the cell the gene product is active
- late endosome
- endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- dendrite
- caveola
- extracellular vesicular exosome
- centriole
- intracellular membrane-bounded organelle
- cilium
- cilium membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- oxysterol binding
- protein kinase A catalytic subunit binding
- patched binding
- cAMP-dependent protein kinase inhibitor activity