Hr Gene Summary [Rat]
This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | Hr |
| Official Name | HR, lysine demethylase and nuclear receptor corepressor [Source:RGD Symbol;Acc:620634] |
| Ensembl ID | ENSRNOG00000011427 |
| Bio databases IDs | |
| Aliases | HR, lysine demethylase and nuclear receptor corepressor |
| Synonyms | ALUNC, AU, bldy, Hairless, HR lysine demethylase and nuclear receptor corepressor, HR, lysine demethylase and nuclear receptor corepressor, HSA277165, HYPT4, lysine demethylase and nuclear receptor corepressor, MUHH, MUHH1, rh-bmh |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- binding protein
- transcription co-repressor
- vitamin D receptor binding
- histone deacetylase binding
- corepressor motif
- thyroid hormone receptor binding domain
- protein binding
- thyroid hormone receptor binding
Pathways
Biological processes and signaling networks where the Hr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrichia with papular lesions
- alopecia
- hyperplasia
- alopecia universalis congenita
- hypotrichosis type 4
- lymphadenopathy
role in cell
- activation in
- number
- apoptosis
- proliferation
- expression in
- quantity
- damage in
- demethylation in
- transactivation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell cortex
- MAD bodies
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- histone deacetylase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- transcription cofactor activity
- protein binding
- metal ion binding
- histone demethylase activity (H3-K9 specific)