Camk2d Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity; nitric-oxide synthase binding activity; and transmembrane transporter binding activity. Involved in several processes, including intracellular monoatomic cation homeostasis; protein phosphorylation; and regulation of calcium ion transmembrane transport. Located in nucleus and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study epilepsy. Biomarker of myocardial infarction and renovascular hypertension. Orthologous to human CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk2d |
| Official Name | calcium/calmodulin-dependent protein kinase II delta [Source:RGD Symbol;Acc:2263] |
| Ensembl ID | ENSRNOG00000011589 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase II delta |
| Synonyms | 2810011D23Rik, 8030469K03Rik, calcium/calmodulin-dependent protein kinase II delta, calcium/calmodulin-dependent protein kinase II, delta, calcium/calmodulin-dependent protein kinase II δ, calcium/calmodulin-dependent protein kinase II, δ, CAMK1, Camk2, CAMK2 delta, CAMK2 δ, CAMKD, Camki, CaMK II, CAMKII delta, CAMKII δ, CAM KINASE II delta C, CaM kinase II δ, CAM KINASE II δ C, [d]-CaMKII, RATCAMKI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camk2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- self-association domain
- calmodulin binding
- Protein tyrosine and serine/threonine kinase
- calmodulin binding domain
- enzyme binding
- SnoaL-like domain
- protein binding
- Protein kinase domain
- identical protein binding
- calmodulin regulated protein kinase
- sodium channel inhibitor
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- cytoskeletal protein binding
- protein homodimerization
- ion channel binding
- NTF2_like
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Camk2d gene in rat plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Calcium Signaling
- Chemokine Signaling
- Circadian Rhythm Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Factors Promoting Cardiogenesis in Vertebrates
- Glioma Signaling
- GM-CSF Signaling
- GNRH Signaling
- HIF1α Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Reelin Signaling in Neurons
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- Parkinson disease
- drug allergy
- humerus fracture
- neurodevelopmental disorder
- heart failure
- dilated cardiomyopathy
- rotator cuff injury
- left ventricular dysfunction
- atrial fibrillation
role in cell
- activation in
- expression in
- depolarization
- phosphorylation in
- formation
- formation in
- proliferation
- quantity
- apoptosis
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- detergent-soluble membrane fractions
- endocytic vesicle membrane
- axon component
- perinuclear region
- cell cortex
- Nucleus
- Plasma Membrane
- intercellular junctions
- cytosol
- nucleoplasm
- neuromuscular junctions
- growth cone
- synaptosomes
- sarcoplasmic reticulum membrane
- synaptic-like microvesicles
- transverse tubules
- secretory granules
- pseudopodia
- perikaryon
- ribbon synapse
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camk2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular localization
- cardiac muscle cell contraction
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- regulation of heart contraction
- protein autophosphorylation
- protein phosphorylation
- regulation of membrane depolarization
- regulation of ryanodine-sensitive calcium-release channel activity
- regulation of transcription from RNA polymerase II promoter
- regulation of the force of heart contraction
- cellular response to calcium ion
- regulation of cell growth
- regulation of cell communication by electrical coupling
- positive regulation of cardiac muscle cell apoptotic process
- positive regulation of cardiac muscle hypertrophy
- regulation of heart rate by cardiac conduction
- endoplasmic reticulum calcium ion homeostasis
- peptidyl-serine phosphorylation
- negative regulation of sodium ion transmembrane transporter activity
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- peptidyl-threonine phosphorylation
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- calcium- and calmodulin-dependent protein kinase complex
- nucleus
- cytoplasm
- sarcolemma
- membrane
- cytosol
- neuron projection
- endocytic vesicle membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- identical protein binding
- protein binding
- protein homodimerization activity
- titin binding
- sodium channel inhibitor activity
- calmodulin-dependent protein kinase activity
- protein serine/threonine kinase activity
- ion channel binding