Slc25a12 Gene Summary [Rat]
Predicted to enable amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to be located in mitochondrial inner membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a12 |
| Official Name | solute carrier family 25 member 12 [Source:RGD Symbol;Acc:1305181] |
| Ensembl ID | ENSRNOG00000022922 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 12 |
| Synonyms | 2610002D09Rik, AGC1, ARALAR, Aralar1, B230107K20RIK, DEE39, EIEE39, LOC100360985, RGD1561141, solute carrier family 25 member 12, solute carrier family 25 (mitochondrial carrier, Aralar), member 12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc25a12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- EF-hand domain pair
- Mitochondrial carrier protein
- sulfur amino acid transporter
- L-amino acid transporter
- dicarboxylic acid transporter
- calcium ion binding
- protein binding
- acidic amino acid transporter
- identical protein binding
- cation transporter
- EFh_PI-PLC
- neutral amino acid transporter
- antiporter
- C4-dicarboxylate transporter
- amino acid transporter
- transporter
- calcium binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- global cerebral hypomyelination
- Crohn disease
- hereditary disorder
- hyperopia
- sporadic amyotrophic lateral sclerosis
- myopia
- mitochondrial disorder
- refractive error
- major depression
- Sengers syndrome
role in cell
- expression in
- cell death
- production in
- hyperpolarization
- respiration in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc25a12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- malate-aspartate shuttle
- aspartate family amino acid metabolic process
- response to calcium ion
- neutral amino acid transport
- L-glutamate transport
- aspartate transport
- L-aspartate transport
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- acidic amino acid transmembrane transporter activity
- L-aspartate transmembrane transporter activity
- L-glutamate transmembrane transporter activity