MCM10 Gene Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
MCM10
Official Name
minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043]
Ensembl ID
ENSG00000065328
Bio databases IDs NCBI: 55388 Ensembl: ENSG00000065328
Aliases minichromosome maintenance 10 replication initiation factor
Synonyms
2410041F14Rik,C330019M07Rik,CNA43,DNA43,IMD80,minichromosome maintenance 10 replication initiation factor,PRO2249
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Mcm10 replication factor
  • enzyme binding
  • Primase zinc finger
  • protein binding
  • identical protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • immunodeficiency 80 with congenital cardiomyopathy
  • organismal death
  • cervical cancer
  • colorectal cancer
  • fetal restrictive cardiomyopathy with lymphoreticular hypoplasia
  • colon carcinoma
  • colon epithelial cancer
regulated by
regulates
role in cell
  • apoptosis
  • cell viability
  • expression in
  • cell death
  • S phase
  • proliferation
  • DNA damage response
  • G2/M phase
  • accumulation
  • shortening

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • soluble fraction
  • chromatin fraction
  • detergent-insoluble fractions
  • insoluble fractions
  • Cytoplasm
  • nuclear foci
  • nucleoplasm
  • nucleoli
  • detergent-soluble fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the MCM10 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • cell proliferation
  • DNA-dependent DNA replication initiation
  • response to DNA damage stimulus

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • nuclear replication fork
  • nucleolus
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • DNA replication origin binding
  • identical protein binding
  • protein binding
  • metal ion binding
  • enzyme binding
  • single-stranded DNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.