CLEC4E Gene Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLEC4E |
| Official Name | C-type lectin domain family 4 member E [Source:HGNC Symbol;Acc:HGNC:14555] |
| Ensembl ID | ENSG00000166523 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4 member E, Macrophage-inducible C-type lectin |
| Synonyms | CLECSF9,C-type lectin domain family 4 member E,C-type lectin domain family 4, member E,C type lectin member 9,MINCLE |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- calcium ion binding
- protein binding
- carbohydrate binding
Pathways
Biological processes and signaling networks where the CLEC4E gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- rheumatoid arthritis
- acute tubular necrosis
- septic shock
- idiopathic pulmonary fibrosis
- experimental autoimmune uveoretinitis
- severe acute respiratory syndrome
- delayed hypersensitive reaction
- dextran sodium sulfate-induced colitis
- infection by fungus
role in cell
- expression in
- apoptosis
- recruitment
- production in
- number
- endocytosis by
- cellular infiltration by
- differentiation
- generation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- cytoplasmic vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CLEC4E gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- innate immune response
- T cell differentiation involved in immune response
- Fc-gamma receptor signaling pathway
- defense response to bacterium
- positive regulation of cytokine production
- pattern recognition receptor signaling pathway
cellular COMPONENT
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- phagocytic vesicle membrane
- phagocytic cup
- cell projection
- plasma membrane
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- glycolipid binding
- calcium ion binding
- carbohydrate binding